CXXC5 Mediates DHT-Induced Androgenetic Alopecia via PGD2

    February 2023 in “ Cells
    Yeong Chan Ryu, Jiyeon Park, You-Rin Kim, Sehee Choi, Geon-Uk Kim, Eunhwan Kim, Yumi Hwang, Heejene Kim, Gyoonhee Han, Soung-Hoon Lee, Kang Yell Choi
    TLDR Targeting CXXC5 and GSK-3β may help treat male pattern baldness.
    The study explores the role of CXXC5 in androgenetic alopecia (AGA), showing that dihydrotestosterone (DHT) and prostaglandin D2 (PGD2) contribute to hair loss by suppressing the Wnt/β-catenin signaling pathway through CXXC5. The research demonstrates that inhibiting CXXC5 and GSK-3β functions can promote hair regrowth, as evidenced by experiments using Cxxc5 knock-out mice and treatments with PTD-DBM and KY19382. These interventions improved hair regrowth and wound-induced hair follicle neogenesis. The findings suggest that targeting CXXC5 and GSK-3β could be an effective treatment for male pattern AGA, highlighting the PGD2–CXXC5 axis as a crucial factor in DHT-induced hair loss.
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