CXXC5 Mediates DHT-Induced Androgenetic Alopecia via PGD2

    February 2023 in “ Cells ”
    Yeong Chan Ryu, Jiyeon Park, You-Rin Kim, Sehee Choi, Geon-Uk Kim, Eunhwan Kim, Yumi Hwang, Heejene Kim, Gyoonhee Han, Soung-Hoon Lee, Kang Yell Choi
    From the encyclopedia
    PTD-DBM →
    KY19382 →

    compound that activates Wnt/β-catenin to promote hair regrowth and create new hair follicles

    Studysummary This study identified CXXC5 as a key mediator of hair loss induced by PGD2 and DHT via suppression of the Wnt/β-catenin pathway, with implications for potential therapeutic targets. Our plain-language summary of this paper — not a Tressless recommendation.
    The study explores the role of CXXC5 in androgenetic alopecia (AGA), showing that dihydrotestosterone (DHT) and prostaglandin D2 (PGD2) contribute to hair loss by suppressing the Wnt/β-catenin signaling pathway through CXXC5. The research demonstrates that inhibiting CXXC5 and GSK-3β functions can promote hair regrowth, as evidenced by experiments using Cxxc5 knock-out mice and treatments with PTD-DBM and KY19382. These interventions improved hair regrowth and wound-induced hair follicle neogenesis. The findings suggest that targeting CXXC5 and GSK-3β could be an effective treatment for male pattern AGA, highlighting the PGD2–CXXC5 axis as a crucial factor in DHT-induced hair loss.
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