Prostaglandin D2, Prostaglandin D2 Receptor, Prostaglandin D2 Synthase

April 2012 in “ Science-business Exchange ”

prostaglandin D2 PGD2 androgenetic alopecia prostaglandin D2 receptor CRTH2 GPR44 CD294 prostaglandin D2 synthase PTGDS hair follicle growth GPR44 antagonists androgenic alopecia hair growth

TLDR Blocking a protein called prostaglandin D2 might help treat hair loss.

Mouse and human studies indicated that inhibiting prostaglandin D2 (PGD2) signaling could be a potential treatment for androgenetic alopecia. The studies found that balding scalp areas in males had higher levels of PGD2 protein compared to areas with hair. Both mouse and human scalp experiments showed that PGD2 inhibited hair follicle growth when compared to a control vehicle. Future research steps involve exploring whether blocking prostaglandin D2 synthase (PTGDS) or the prostaglandin D2 receptor (GPR44) could enhance hair growth. Additionally, at least nine companies were reported to have GPR44 antagonists in Phase II trials or earlier stages of development for treating allergies or asthma. A patent application had been filed and the findings were available for licensing.

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research Prostaglandin D2, Prostaglandin D2 Receptor, Prostaglandin D2 Synthase

2 citations, April 2012 in “Science-business Exchange”

Blocking a protein called prostaglandin D2 might help treat hair loss.