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GlossaryGPR44

protein receptor involved in immune response and inflammation

GPR44, also known as CRTH2 or the DP2 receptor, is a type of protein found on the surface of certain cells that plays a role in the body's immune response. It is involved in the process of inflammation and allergic reactions by binding to prostaglandin D2, a molecule that can cause symptoms like itching, swelling, and redness. This receptor is also being studied for its potential role in conditions like asthma and alopecia, where it may influence hair growth and immune system activity.

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research Prostaglandin D2 Inhibits Wound-Induced Hair Follicle Neogenesis Through the Receptor Gpr44

68 citations , November 2012 in “Journal of Investigative Dermatology”

Prostaglandin D2 blocks new hair growth after skin injury through the Gpr44 receptor.

research Prostaglandin D2, Prostaglandin D2 Receptor, Prostaglandin D2 Synthase

2 citations , April 2012 in “Science-business Exchange”

Blocking a protein called prostaglandin D2 might help treat hair loss.

research Prostaglandin D2 Inhibits Hair Growth and Is Elevated in Bald Scalp of Men with Androgenetic Alopecia

205 citations , March 2012 in “Science Translational Medicine”

PGD2 stops hair growth and is higher in bald men with AGA.

research Does Prostaglandin D2 Hold the Cure to Male Pattern Baldness?

57 citations , February 2014 in “Experimental Dermatology”

Prostaglandin D₂ might be targeted for new male pattern baldness treatments.

research Clues About The Causes Of Male Pattern Baldness

June 2012 in “Nature digest”

A substance called prostaglandin D2 is linked to stopping hair growth in men with common baldness.

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community Need supplemental products in addition to oral minoxidil and oral dutasteride

in Product 1 upvotes 1 month ago

The user has been using oral minoxidil and dutasteride for hair loss without success and is considering adding topical 17α-estradiol, Pyrilutamide, Clascoterone, or cetirizine. They have confirmed low serum DHT levels and are exploring additional treatments due to genetic sensitivity to DHT and prostaglandin D2.

community What should I expect from dutasteride?

in Finasteride/Dutasteride 2 upvotes 4 years ago

The user tried Minoxidil, PRP, Hair Carboxytherapy, and topical Dutasteride with limited success and is now on oral Dutasteride. They are experiencing some hair loss reduction but no significant density improvement, leading to feelings of depression.

community Fevipiprant 2019!

17 upvotes 8 years ago

The conversation discusses Fevipiprant, an asthma drug that may block CRTH2 and potentially stop male pattern baldness (MPB) without inhibiting DHT. It also mentions the use of finasteride and dutasteride for hair loss.