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Glossary Progesterone Receptor

protein in cells that binds to the hormone progesterone

The Progesterone Receptor (PR) is a protein found inside cells that binds to the hormone progesterone. This receptor is crucial for regulating various reproductive processes, including the menstrual cycle and pregnancy. In the context of hair and alopecia, PRs can influence hair growth cycles and are a target for treatments aimed at conditions like androgenetic alopecia.

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Research

5 / 1000+ results

research Anticonvulsant Activity of Progesterone and Neurosteroids in Progesterone Receptor Knockout Mice

180 citations , June 2004 in “Journal of Pharmacology and Experimental Therapeutics”

This study found that progesterone's antiseizure effects in mice occurred primarily through conversion to allopregnanolone, rather than through the progesterone receptor, as evidenced by results in PR knockout mice.

research Anesthetic effects of progesterone are undiminished in progesterone receptor knockout mice

35 citations , January 2005 in “Brain Research”

This study indicates that progesterone’s anesthetic activity in PR knockout mice is not due to progesterone receptors but is partially mediated by the neurosteroid allopregnanolone through GABAA receptor potentiation.

research Estrogen and Progesterone Receptors in Androgenic Alopecia Versus Alopecia Areata

27 citations , April 1998 in “American Journal of Dermatopathology”

This study found no significant difference in estrogen and progesterone receptor expression between androgenic alopecia and alopecia areata, suggesting an indirect hormonal influence on androgenic alopecia.

research Respiratory regulation by steroids in newborn rats: a sex‐specific balance between allopregnanolone and progesterone receptors

17 citations , November 2017 in “Experimental physiology”

This study found that in newborn rats, progesterone's effects on apnoea frequency are influenced by a sex-specific balance between its metabolite allopregnanolone and progesterone receptors.

research Testosterone and Progesterone Levels, Gene Expression of Androgen and Progesterone Receptors in Albino Male Rats Treated with Phenolic Flower Extract of Hibiscus Rosa - Sinensis L

1 citations , April 2020 in “Medico-Legal Update”

This study found that phenolic extract from Hibiscus rosa-sinensis flowers significantly decreased testosterone, progesterone levels, and androgen receptor expression in male rats over 60 days.

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Community Join

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community Is there a topical androgen receptor blocker so we don't have to fuck with the enzyme and destroy our allopregnanolone, but go and hit the end target straight?

in Treatment 44 upvotes 2 years ago

The conversation discusses topical androgen receptor blockers for hair loss, mentioning Clascoterone, Pyrilutamide, GT20029, and RU58841. Ketoconazole's effectiveness and application methods are also debated.

community 1 year of finasteride, minoxidil and dutasteride

902 upvotes 2 months ago

A 26-year-old shared their successful hair regrowth journey using finasteride, minoxidil, and dutasteride, along with a custom minoxidil solution containing progesterone, cortisone, alpha 5 estradiol, menthol, caffeine, and melatonin. They experienced no side effects but noted that stopping the medications would reverse the progress.

community Hair regrow idea: High dose Testosterone + RU58841

in Satire 2 upvotes 4 months ago

Using high doses of testosterone with RU58841 to create an androgen-free environment for hair regrowth is suggested, but concerns about heart health and the effectiveness of this approach are raised. Alternatives like topical estrogen, progesterone, and other treatments like finasteride and dutasteride are discussed.

community SOS – The cure for women = PREGNANCY

2 upvotes 7 months ago

Pregnancy can temporarily reverse hair loss in women, but attempts to mimic pregnancy hormones with treatments like contraceptive pills, spironolactone, estradiol, progesterone, finasteride, and minoxidil have been ineffective. The discussion highlights the need for research into the hormonal mechanisms of pregnancy that affect hair regrowth.

community Female, 30, PCOS diagnosis, MPB Norwood 2. Endo refuses to give anything other than Spironolactone. Feel like I’m at my wit’s end here.

55 upvotes 2 years ago

A 30-year-old female with PCOS and male pattern baldness is frustrated with her endocrinologist's recommendation of only Spironolactone and minoxidil, feeling that dutasteride, finasteride, and progesterone would be more effective. Other users suggest various online sources for treatments, warn against self-medicating due to potential risks, and recommend seeking a specialized endocrinologist or considering additional treatments like Inositol, Berberine, and dermaneedling.

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