Testosterone and Progesterone Levels, Gene Expression of Androgen and Progesterone Receptors in Albino Male Rats Treated with Phenolic Flower Extract of Hibiscus Rosa-Sinensis L

April 2020 in “ Medico-Legal Update ”

Rawaa S.A.AL-Azawi., Faris N. A. Alhady

testosterone progesterone androgen receptors progesterone receptors phenolic extract Hibiscus rosa-sinensis testicular cells hibiscus flower extract

TLDR The flower extract lowered testosterone, progesterone, and related gene expression in male rats.

The study evaluated the effects of phenolic extract from Hibiscus rosa-sinensis L. flowers on testosterone and progesterone levels, as well as gene expression of androgen and progesterone receptors in 32 albino male rats. Results indicated a significant decrease (p<0.05) in testosterone and progesterone levels, and a significant reduction (p<0.05) in the expression of androgen and progesterone receptors in testicular cells of treated rats compared to control groups after 30 and 60 days of treatment with 300 mg/kg/day of the extract.

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