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Glossary Leucine-rich repeat-containing G-protein coupled receptor

protein on cell surface involved in cell signaling

Leucine-rich repeat-containing G-protein coupled receptors (LGRs) are a type of protein found on the surface of cells that play a crucial role in cell signaling. They are involved in various biological processes, including hormone regulation and development, by transmitting signals from outside the cell to the inside. These receptors are characterized by the presence of leucine-rich repeats, which are specific sequences of amino acids that help the receptor bind to its specific ligands.

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research Leucine-Rich Repeat-Containing G-Protein-Coupled Receptors as Markers of Adult Stem Cells

291 citations , April 2010 in “Gastroenterology”

This study identified Lgr5 and Lgr6 as receptors expressed by small populations of stem cells in various adult organs, with Lgr5+ve cells forming long-lived organoids in certain mouse models.

research Tissue Engineering and Regeneration of the Human Hair Follicle in Androgenetic Alopecia: Literature Review

4 citations , January 2022 in “Life”

This review examines current and potential tissue engineering strategies for hair follicle regeneration in androgenetic alopecia but does not provide new clinical results, highlighting the need for further research and development.

research Transcriptome Profiling and Differential Gene Expression in Canine Microdissected Anagen and Telogen Hair Follicles and Interfollicular Epidermis

7 citations , August 2020 in “Genes”

This study mapped gene expression in different skin structures of dogs, finding similarities to humans that support using dogs as models for human skin diseases.

research Tracing the cellular origin of cancer

232 citations , January 2013 in “Nature Cell Biology”

Understanding where cancer cells come from helps create better prevention and treatment methods.

research In vitro hair growth‐promoting effect of Lgr5‐binding octapeptide in human primary hair cells

October 2023 in “Journal of Cosmetic Dermatology”

This study found that an octapeptide binding to Lgr5 can enhance the proliferation and differentiation of human primary hair cells by activating the Wnt/β-catenin signaling pathway, suggesting its potential as a treatment for hair loss in androgenetic alopecia.

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