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Glossary Leucine-rich repeat-containing G-protein coupled receptor

protein on cell surface involved in cell signaling

Leucine-rich repeat-containing G-protein coupled receptors (LGRs) are a type of protein found on the surface of cells that play a crucial role in cell signaling. They are involved in various biological processes, including hormone regulation and development, by transmitting signals from outside the cell to the inside. These receptors are characterized by the presence of leucine-rich repeats, which are specific sequences of amino acids that help the receptor bind to its specific ligands.

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research Leucine-Rich Repeat-Containing G-Protein-Coupled Receptors as Markers of Adult Stem Cells

291 citations , April 2010 in “Gastroenterology”

This study identified Lgr5 and Lgr6 as receptors expressed by small populations of stem cells in various adult organs, with Lgr5+ve cells forming long-lived organoids in certain mouse models.

research Tissue Engineering and Regeneration of the Human Hair Follicle in Androgenetic Alopecia: Literature Review

4 citations , January 2022 in “Life”

This review examines current and potential tissue engineering strategies for hair follicle regeneration in androgenetic alopecia but does not provide new clinical results, highlighting the need for further research and development.

research Transcriptome Profiling and Differential Gene Expression in Canine Microdissected Anagen and Telogen Hair Follicles and Interfollicular Epidermis

7 citations , August 2020 in “Genes”

This study mapped gene expression in different skin structures of dogs, finding similarities to humans that support using dogs as models for human skin diseases.

research Tracing the cellular origin of cancer

232 citations , January 2013 in “Nature Cell Biology”

Understanding where cancer cells come from helps create better prevention and treatment methods.

research In vitro hair growth‐promoting effect of Lgr5‐binding octapeptide in human primary hair cells

October 2023 in “Journal of Cosmetic Dermatology”

This study found that an octapeptide binding to Lgr5 can enhance the proliferation and differentiation of human primary hair cells by activating the Wnt/β-catenin signaling pathway, suggesting its potential as a treatment for hair loss in androgenetic alopecia.

research Neurobiology, Stem Cell Biology, and Immunology: An Emerging Triad for Understanding Tissue Homeostasis and Repair

1 citations , October 2022 in “Annual review of cell and developmental biology”

This review discusses the roles of peripheral nerves in stem cell and immune responses within the skin and hematopoietic system, emphasizing their potential in developing new therapies; it reports no new experimental results.

research Hair Follicle Stem Cell SLC3A2 Regulates Epithelial Regenerative Properties

September 2025 in “Journal of Investigative Dermatology”

This research found that deleting the SLC3A2 gene in hair follicle stem cells disrupts their maintenance and proper differentiation, leading to hair follicle growth defects and altered skin regeneration through a YAP/Taz-dependent pathway.

research A matter of life and death: self‐renewal in stem cells

150 citations , December 2012 in “EMBO Reports”

This review explores the mechanisms of adult stem cell self-renewal, using skin as a model, and reports no new results but raises important unanswered questions in the field.

research Matrisomal components involved in regenerative wound healing in axolotl and Acomys: implications for biomaterial development

January 2023 in “Biomaterials Science”

This study suggests that incorporating matrisomal components into biomaterials could enhance skin wound healing in mammals that do not naturally regenerate tissues like the axolotl and Acomys.

research Hair, Cutaneous Homeostasis and Stem Cell Functions

January 2014 in “Journal of Investigative Dermatology”

Proteins like aPKC and PDGF-AA, substances like adenosine and ATP, and adipose-derived stem cells all play important roles in hair growth and health, and could potentially be used to treat hair loss and skin conditions.

research Proinflammatory cytokines regulate epidermal stem cells in wound epithelialization

65 citations , June 2020 in “Stem Cell Research & Therapy”

This review discusses recent advances in how proinflammatory cytokines affect epidermal stem cell function during skin wound healing and introduces potential therapies targeting these cells and cytokines.

research Skin cancer: understanding the journey of transformation from conventional to advanced treatment approaches

16 citations , October 2023 in “Molecular cancer”

This study reviews the etiology and treatment of skin cancer, focusing on nanotechnology's role in addressing drug resistance and evaluating nanoparticles' potential to improve treatment outcomes, including overcoming multidrug resistance.

research dsRNA Released by Tissue Damage Activates TLR3 to Drive Skin Regeneration

128 citations , August 2015 in “Cell Stem Cell”

The researchers reported that dsRNA from damaged skin activates TLR3, promoting hair follicle regeneration, while TLR3-deficient animals fail to initiate this process, suggesting potential therapeutic approaches for hair neogenesis.

research Androgenetic alopecia: combing the hair follicle signaling pathways for new therapeutic targets and more effective treatment options

19 citations , August 2019 in “Expert Opinion on Therapeutic Targets”

This review discusses emerging targets for developing drugs to treat hair loss and reports no new clinical results; the authors emphasize the potential for therapies that regenerate hair follicles.

research A practical guide for the study of human and murine sebaceous glands in situ

56 citations , September 2013 in “Experimental Dermatology”

This guide reviews the biology of sebaceous glands and their evaluation methods, emphasizing their roles beyond lipid production in skin health and disease, and reports no new research results.

research Signaling and Gene Expression for Water-Tolerant Legume Nodulation

22 citations , August 2006 in “Critical Reviews in Plant Sciences”

The tropical legume Sesbania rostrata can form nodules in waterlogged conditions using a different method that involves plant hormones and specific genes.

research Stem cell plasticity enables hair regeneration following Lgr5+ cell loss

56 citations , May 2017 in “Nature Cell Biology”

Hair can regrow after certain stem cells are lost because other stem cells can take over their role.

research The TOR–Auxin Connection Upstream of Root Hair Growth

20 citations , January 2021 in “Plants”

This review discusses the role of PIN-FORMED 2 and related signaling pathways in root hair growth regulation and reports no new experimental findings.

research The Browning of White Adipose Tissue: Some Burning Issues

437 citations , August 2014 in “Cell metabolism”

This perspective suggests that browning agents may not directly enhance UCP1 expression in white adipose tissue but instead induce browning through increased heat loss, prompting thermogenesis to compensate.

research Injury-induced interleukin-1 alpha promotes Lgr5 hair follicle stem cells de novo regeneration and proliferation via regulating regenerative microenvironment in mice

7 citations , February 2023 in “Inflammation and Regeneration”

This study found that IL-1α promotes hair follicle regeneration and stem cell activation in an age-dependent manner by modulating inflammatory cells and oxidative stress in mice.

research Sebaceous immunobiology - skin homeostasis, pathophysiology, coordination of innate immunity and inflammatory response and disease associations

21 citations , November 2022 in “Frontiers in immunology”

This article reviews sebaceous immunobiology and highlights the complex role of sebaceous glands and sebocytes in skin barrier function and inflammation, particularly in acne pathogenesis, but reports no new results.

research Transient Ca2+ entry by plasmalogen-mediated activation of receptor potential cation channel promotes AMPK activity

3 citations , November 2022 in “Frontiers in molecular biosciences”

This study suggests that in mice, plasmalogens may enhance hair growth by activating TRPC4 channels, which increases calcium influx and subsequently stimulates AMPK in hair follicles.

research The Immune Functions of Keratinocytes in Skin Wound Healing

147 citations , November 2020 in “International Journal of Molecular Sciences”

This review discusses the immune roles of keratinocytes in wound healing and chronic wound inflammation, emphasizing their potential impact on chronic wound pathology and highlighting areas for future research.

research Treatment of Full-Thickness Skin Wounds with Blood-Derived CD34+ Precursor Cells Enhances Healing with Hair Follicle Regeneration

2 citations , May 2019 in “Advances in wound care”

In this study, nondermal-derived CD34+ cells from adult peripheral blood were found to enhance wound healing and contribute to hair follicle neogenesis and skin regeneration.

research Comparative regenerative mechanisms across different mammalian tissues

252 citations , February 2018 in “npj Regenerative Medicine”

This review explores recent advances in understanding molecular mechanisms of tissue regeneration in mammals and suggests potential therapeutic targets, but it reports no new clinical results.

research Stem Cells and the Niche: A Dynamic Duo

333 citations , February 2010 in “Cell Stem Cell”

This review discusses experimental data, technologies, and genetic factors related to stem cell niches, highlighting their role in tissue regeneration and diseases, but reports no new results.

research Aligned membranes regulate wound healing via MMP12 secreted by macrophages

January 2025 in “PLoS ONE”

This study found that aligned electrospinning membranes enhance skin wound healing by upregulating MMP12 expression and inhibiting fibroblast migration, which results in reduced scar formation, providing valuable insights for developing more effective biological dressings.

research Study of gene expression alteration in male androgenetic alopecia: evidence of predominant molecular signalling pathways

27 citations , April 2017 in “British Journal of Dermatology”

This study identified overexpression of certain immune-related genes and underexpression of genes in specific signaling pathways in premature androgenetic alopecia, suggesting potential new therapeutic targets.

research Understanding Cancer Cells of Origin in Cutaneous Tumors

1 citations , January 2016 in “Elsevier eBooks”

This review examines the origins and mechanisms of tumor initiation in common skin cancers, but does not present new experimental findings; it emphasizes the need for further research on cancer stem cells.

research NF-κB in biology and targeted therapy: new insights and translational implications

1 citations , March 2024 in “Signal transduction and targeted therapy”

In this review, researchers explored the multifaceted role of NF-κB signaling in various biological processes and diseases, including its interactions with other pathways, and discussed possible therapeutic approaches targeting this pathway for treating conditions like cancer, autoimmune disorders, and COVID-19.