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GlossaryGPR44 (CRTH2)

protein receptor involved in immune response and inflammation

GPR44, also known as CRTH2 or the DP2 receptor, is a type of protein found on the surface of certain cells that plays a role in the body's immune response. It is involved in the process of inflammation and allergic reactions by binding to prostaglandin D2, a molecule that can cause symptoms like itching, swelling, and redness. This receptor is also being studied for its potential role in conditions like asthma and alopecia, where it may influence hair growth and immune system activity.

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research The Therapeutic Potential of CRTH2/DP2 Beyond Allergy and Asthma

24 citations, August 2017 in “Prostaglandins & Other Lipid Mediators”

CRTH2 antagonists might be useful for treating many conditions because they play a role in immune and inflammation responses.

Verification of the Major Metabolic Oxidation Path for the Naphthoyl Group in Chemoattractant Receptor-Homologous Molecule Expressed on Th2 Cells (CRTh2) Antagonist 2-(2-(1-Naphthoyl)-8-fluoro-3,4-dihydro-1H-pyrido[4,3-b]indol-5(2H)-yl)acetic Acid (Setipiprant/ACT-129968)

research Verification of the Major Metabolic Oxidation Path for the Naphthoyl Group in Chemoattractant Receptor-Homologous Molecule Expressed on Th2 Cells (CRTh2) Antagonist 2-(2-(1-Naphthoyl)-8-fluoro-3,4-dihydro-1H-pyrido[4,3-b]indol-5(2H)-yl)acetic Acid (Setipiprant/ACT-129968)

6 citations, September 2015 in “Journal of Medicinal Chemistry”

The document confirms the structures of major metabolites of the CRTh2 antagonist Setipiprant and identifies minor metabolites.

research Prostaglandin D2, Prostaglandin D2 Receptor, Prostaglandin D2 Synthase

2 citations, April 2012 in “Science-business Exchange”

Blocking a protein called prostaglandin D2 might help treat hair loss.

research Setipiprant for Androgenetic Alopecia in Males: Results from a Randomized, Double-Blind, Placebo-Controlled Phase 2a Trial

3 citations, October 2021 in “Clinical, Cosmetic and Investigational Dermatology”

Setipiprant did not significantly improve hair growth in men with hair loss.

research Expression Level of Prostaglandin D2 Receptor 2 Regulates Hair Regression

2 citations, February 2019 in “Journal of Investigative Dermatology”

Higher levels of the DP2 receptor may lead to hair loss.

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community Fevipiprant 2019!

17 upvotes 8 years ago

The conversation discusses Fevipiprant, an asthma drug that may block CRTH2 and potentially stop male pattern baldness (MPB) without inhibiting DHT. It also mentions the use of finasteride and dutasteride for hair loss.

community Cassiopea announces completion of recruitment of Phase II dose ranging trial of Breezula (CB-03-01) for androgenic alopecia

11 upvotes 6 years ago

The conversation discusses the completion of a Phase II trial recruitment for Breezula (CB-03-01), a potential treatment for androgenic alopecia. Specific treatments mentioned include Minoxidil, Finasteride, and RU58841.

community SETIPIPRANT PGE2 GROUP BUY AND PIONEERING HAIR GROWTH

7 upvotes 8 years ago

The conversation is about a user seeking help with hair regrowth treatments, specifically mentioning Setipiprant, Minoxidil, Finasteride, and RU58841. The user is trying to contact forum members for guidance on making and using these treatments.

community The New, Improved CB-03-01/Setipiprant Group Buy

27 upvotes 8 years ago

The group buy for CB-03-01, a topical anti-androgen for hair loss, was postponed and refunded due to issues with the product's form and solubility. The product, also known as Breezula, is an alternative to finasteride with fewer side effects, but its official release is delayed until 2021.