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GlossaryGPR44 (CRTH2)

protein receptor involved in immune response and inflammation

GPR44, also known as CRTH2 or the DP2 receptor, is a type of protein found on the surface of certain cells that plays a role in the body's immune response. It is involved in the process of inflammation and allergic reactions by binding to prostaglandin D2, a molecule that can cause symptoms like itching, swelling, and redness. This receptor is also being studied for its potential role in conditions like asthma and alopecia, where it may influence hair growth and immune system activity.

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research Prostaglandin D2, Prostaglandin D2 Receptor, Prostaglandin D2 Synthase

2 citations, April 2012 in “Science-business Exchange”

Blocking a protein called prostaglandin D2 might help treat hair loss.

research Setipiprant for Androgenetic Alopecia in Males: Results from a Randomized, Double-Blind, Placebo-Controlled Phase 2a Trial

3 citations, October 2021 in “Clinical, Cosmetic and Investigational Dermatology”

Setipiprant did not significantly improve hair growth in men with hair loss.

Verification of the Major Metabolic Oxidation Path for the Naphthoyl Group in Chemoattractant Receptor-Homologous Molecule Expressed on Th2 Cells (CRTh2) Antagonist 2-(2-(1-Naphthoyl)-8-fluoro-3,4-dihydro-1H-pyrido[4,3-b]indol-5(2H)-yl)acetic Acid (Setipiprant/ACT-129968)

research Verification of the Major Metabolic Oxidation Path for the Naphthoyl Group in Chemoattractant Receptor-Homologous Molecule Expressed on Th2 Cells (CRTh2) Antagonist 2-(2-(1-Naphthoyl)-8-fluoro-3,4-dihydro-1H-pyrido[4,3-b]indol-5(2H)-yl)acetic Acid (Setipiprant/ACT-129968)

6 citations, September 2015 in “Journal of Medicinal Chemistry”

The document confirms the structures of major metabolites of the CRTh2 antagonist Setipiprant and identifies minor metabolites.

research Therapeutic Implications of Topical Cetirizine 1% in Treatment of Male Androgenetic Alopecia: A Case-Controlled Study

5 citations, January 2021 in “Journal of Cosmetic Dermatology”

Topical cetirizine 1% promotes hair growth in male androgenetic alopecia patients.

research Conflicting Auxin-Phosphate Signals Impact on RSL2 Expression and ROS Homeostasis Linked to Root Hair Growth in Arabidopsis

January 2018 in “bioRxiv (Cold Spring Harbor Laboratory)”

Auxin helps root hairs grow in high phosphate by affecting ROS and involving RSL2 and RSL4.