Hair Loss And Regeneration Performed On Animal Models

October 2015 in “ Medicine and Pharmacy Reports ”

Meda Sandra Orăsan, Iulia Ioana Roman, Andrei Coneac, Adriana Mureşan, Remus Ioan Orăsan

Minoxidil Finasteride 5 alpha-reductase inhibitor dermal papilla Arginin Aminexil SP94 peptide vitamins B5 vitamins B6 Thermal Spring Water Low Level Laser Therapy LLLT Rogaine Propecia Laser Therapy

TLDR Animal models are crucial for learning about hair loss and finding treatments.

The 2016 document reviews the state of hair loss and regeneration research, focusing on the two FDA-approved treatments at the time: Minoxidil and Finasteride. It discusses the biological and psychological aspects of hair loss, the importance of the dermal papilla in hair growth, and the need for better standardized methods for evaluating hair loss and regrowth. Finasteride, a 5 alpha-reductase inhibitor, was shown to stop hair fall in 48% of cases and stimulate regrowth in 51% of cases, with a minimum of 4 months of daily use required and cessation of effects upon stopping treatment. The document also explores other potential treatments like Arginin, Aminexil 1.5%, SP94 peptide, vitamins B5 and B6, Thermal Spring Water, and Low Level Laser Therapy (LLLT). It emphasizes the value of animal models in hair research due to ethical and practical limitations in human studies and concludes that these models are essential for understanding hair diseases and developing cures.

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research The Current Role of Laser and Light Sources in the Treatment of Male and Female Pattern Hair Loss

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research Burden of Hair Loss: Stress and the Underestimated Psychosocial Impact of Telogen Effluvium and Androgenetic Alopecia

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research A Randomized, Placebo-Controlled Trial of 5% and 2% Topical Minoxidil Solutions in the Treatment of Female Pattern Hair Loss

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research Androgenetic Alopecia: Pathogenesis and Potential for Therapy

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research The Psychology of Hair Loss and Its Implications for Patient Care

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Measuring Reversal of Hair Miniaturization in Androgenetic Alopecia by Follicular Counts in Horizontal Sections of Serial Scalp Biopsies: Results of Finasteride 1mg Treatment of Men and Postmenopausal Women

research Measuring Reversal of Hair Miniaturization in Androgenetic Alopecia by Follicular Counts in Horizontal Sections of Serial Scalp Biopsies: Results of Finasteride 1mg Treatment of Men and Postmenopausal Women

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research Androgenetic Alopecia: In Vivo Models

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research Balding Hair Follicle Dermal Papilla Cells Contain Higher Levels of Androgen Receptors Than Those From Non-Balding Scalp

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research Whole Hair Follicle Culture

57 citations , October 1996 in “Dermatologic clinics”

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research Mouse Models for the Study of Human Hair Loss

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research Psychological Effects of Androgenetic Alopecia on Women: Comparisons with Balding Men and Female Control Subjects

222 citations , October 1993 in “Journal of The American Academy of Dermatology”

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research The Psychological Effects of Androgenetic Alopecia in Men

192 citations , June 1992 in “Journal of The American Academy of Dermatology”

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research Cultured Dermal Papilla Cells From Androgen-Dependent Human Hair Follicles Contain More Androgen Receptors Than Those From Non-Balding Areas Of Scalp

124 citations , April 1992 in “Journal of Endocrinology/Journal of endocrinology”

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research Human Hair Growth In Vitro

385 citations , November 1990 in “Journal of Cell Science”

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research The Effect of Topical Minoxidil on Hair Follicular Cycles of Rats

53 citations , May 1990 in “Journal of Dermatology”

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research Animal Models of Androgen-Dependent Disorders of the Pilosebaceous Apparatus

38 citations , July 1989 in “Archives of dermatological research”

Testosterone causes hair loss in AGA mice, which are good for testing baldness treatments, and both minoxidil and cyproterone acetate can prevent this hair loss.

research Long-Term Follow-Up of Men with Male Pattern Baldness Treated with Topical Minoxidil

51 citations , March 1987 in “Journal of The American Academy of Dermatology”

Minoxidil keeps most hair growth from first year and twice-daily use is better with few side effects.

research Classification of the Types of Androgenetic Alopecia (Common Baldness) Occurring in the Female Sex

666 citations , September 1977 in “British Journal of Dermatology”

Common baldness, also known as Androgenetic Alopecia, is caused by a combination of genetic factors and hormones called androgens.

research Critical Stages of Hair Development and Pigmentation in the Mouse

236 citations , January 1951 in “Physiological zoology”

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