Critical Factors in Sample Collection and Preparation for Clinical Metabolomics of Underexplored Biological Specimens
January 2024
in “
Metabolites
”
Studysummary This review highlights the importance of standardizing pre-analytical procedures for collecting and extracting samples from uncommon biological specimens like breast milk and sweat in clinical metabolomics, to enhance diagnostic and biomarker discovery efforts while minimizing contamination and bias.
Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer
The review article emphasizes the importance of meticulous pre-collection, collection, and extraction conditions in clinical metabolomics studies, particularly for underexplored biological specimens such as hair, saliva, cerebrospinal fluid, and others. It highlights the need for standardized protocols to ensure accurate and reproducible results, considering factors like diet, medication, and hygiene. The review discusses various collection methods, storage conditions, and extraction procedures, underscoring the potential of these specimens in biomarker discovery and disease diagnosis, including conditions like androgenetic alopecia, oral cancer, diabetes, and Alzheimer's disease.
