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GlossaryCerebrospinal Fluid

clear fluid cushioning brain and spinal cord

Cerebrospinal Fluid (CSF) is a clear, colorless liquid that surrounds and cushions the brain and spinal cord, providing mechanical protection and maintaining a stable environment for the central nervous system. It also plays a role in removing waste products from the brain and distributing nutrients and hormones.

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Neuroactive Steroid Levels Are Modified in Cerebrospinal Fluid and Plasma of Post-Finasteride Patients Showing Persistent Sexual Side Effects and Anxious/Depressive Symptomatology

research Neuroactive Steroid Levels Are Modified in Cerebrospinal Fluid and Plasma of Post-Finasteride Patients Showing Persistent Sexual Side Effects and Anxious/Depressive Symptomatology

73 citations , July 2013 in “The Journal of Sexual Medicine”

Finasteride use changes brain chemicals, causing lasting sexual issues and anxiety/depression.

Patients Treated for Male Pattern Hair Loss with Finasteride Show Altered Levels of Neuroactive Steroids in Cerebrospinal Fluid and Plasma After Discontinuation

research Patients Treated for Male Pattern Hair Loss with Finasteride Show Altered Levels of Neuroactive Steroids in Cerebrospinal Fluid and Plasma After Discontinuation

61 citations , April 2014 in “The Journal of Steroid Biochemistry and Molecular Biology”

Finasteride affects brain and blood steroids, causing lasting sexual and emotional side effects.

research Weak Correlations Between Serum and Cerebrospinal Fluid Levels of Estradiol, Progesterone, and Testosterone in Males

19 citations , October 2019 in “BMC Neuroscience”

Blood hormone levels don't accurately show brain hormone levels in males.

research Sex Steroid Levels in Cerebrospinal Fluid and Serum Samples Quantified by Mass Spectrometry in Men

1 citations , November 2023 in “Endocrine Connections”

DHEA is the main sex steroid in cerebrospinal fluid, and testosterone in the fluid comes from the blood.

Corrigendum to Patients Treated for Male Pattern Hair Loss With Finasteride Show, After Discontinuation of the Drug, Altered Levels of Neuroactive Steroids in Cerebrospinal Fluid and Plasma

research Corrigendum to Patients Treated for Male Pattern Hair Loss With Finasteride Show, After Discontinuation of the Drug, Altered Levels of Neuroactive Steroids in Cerebrospinal Fluid and Plasma

September 2023 in “The Journal of Steroid Biochemistry and Molecular Biology”

Stopping finasteride for male pattern hair loss changes neuroactive steroid levels in the brain and blood.

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community Possible natural pp405 solution

in Research/Science 45 upvotes 3 months ago

Rotenone, a natural plant extract, may promote hair growth by increasing LDH activity and blocking MPC in the scalp, but it carries risks due to its toxicity. The suggested formulation includes Barbasco extract, DMSO, propylene glycol or PEG-400, ethanol, and a carrier oil.

community 5 alpha reductase type 1 is in brain tissue producing the main endogenous gabaergic allopregnanolone, not 2. How can finasteride as a 5ar2 lower that?

in Finasteride/Dutasteride 27 upvotes 1 year ago

Finasteride and dutasteride are discussed for hair loss, with concerns about their effects on neurosteroids and potential side effects like depression. Alternatives like topical estrogen and lifestyle changes are considered, with varying opinions on mental health and hair regrowth.

community Creatine is the opposite of minoxidil !

in Research/Science 325 upvotes 1 month ago

Creatine may counteract minoxidil's hair growth effects by closing potassium ATP channels, potentially leading to hair loss in predisposed individuals. Despite anecdotal reports, there is no conclusive evidence linking creatine to hair loss.

community Finasteride does deplete important nuero-active steroids

in Research/Science 9 upvotes 2 years ago

Finasteride can reduce neuroactive steroids, causing side effects like depression, anxiety, and sexual dysfunction. Some users experience persistent symptoms after stopping finasteride, while others use alternative treatments like topical solutions.

community Why I deleted my YouTube channel Part I

in Update 118 upvotes 4 years ago

A YouTuber named Kevin, also known as Rider_Of_Roach, who deleted his YouTube channel due to personal attacks and controversy surrounding his views on hair loss treatments. He advocated for FDA-approved treatments like finasteride and minoxidil but faced backlash from those who disagreed with him. The conversation also discusses his past trolling behavior and a lawsuit he filed against a website that published false information about him. Despite some disagreements, many viewers appreciated his research-based content and hope to see him return in the future.