The Role of Extracellular Vesicles in the Development and Treatment of Psoriasis: Narrative Review

    December 2024 in “ Pharmaceutics ”
    Bin Tang, Yang Bi, Xuwei Zheng, Yujie Yang, Xiaobing Huang, Kexin Yang, Haixin Zhong, Ling Han, Chuanjian Lu, Haiming Chen
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    TLDR Extracellular vesicles show promise for treating psoriasis by reducing inflammation and skin lesions.
    This narrative review examines the role of extracellular vesicles (EVs) in psoriasis, emphasizing their potential as biomarkers and therapeutic agents. EVs, including exosomes and microvesicles, are involved in immune modulation and intercellular communication, making them promising for disease treatment. The review highlights the therapeutic potential of EVs, particularly those derived from mesenchymal stem cells (MSCs), in reducing inflammation and skin lesions in psoriasis models. EVs can be used directly as treatments or as vehicles for drug delivery, offering a novel approach to current treatment challenges. Despite promising findings, further research is needed to address challenges like EV heterogeneity and delivery efficiency to fully harness their therapeutic potential.
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