Exosomes Secreted from Adipose-Derived Stem Cells Are a Potential Treatment Agent for Immune-Mediated Alopecia

The study investigated the effects of exosomes from adipose-derived stem cells (ADSC-Exos) on hair growth, particularly in immune-mediated alopecia. In vitro, ADSC-Exos promoted the proliferation and migration of dermal papilla cells (DPCs) and reduced apoptosis. In vivo, using a C57BL/6 hair-depilated mouse model, ADSC-Exos-treated mice showed improved hair growth, more hair follicles, and a thicker dermis compared to the control group. The study also found that the miR-22 and TNF-α signaling pathways were significantly downregulated in DPCs after ADSC-Exos treatment, and the Wnt/β-catenin signaling pathway was activated in the skin of ADSC-Exos-treated mice. The study concluded that ADSC-Exos therapy positively affected hair regrowth by regulating these pathways, suggesting that ADSC-Exos could be a promising cell-free therapeutic strategy for immune-mediated alopecia.