Exosomes Secreted from Adipose-Derived Stem Cells Are a Potential Treatment Agent for Immune-Mediated Alopecia
February 2022
in “
Journal of immunology research
”
exosomes adipose-derived stem cells ADSC-Exos immune-mediated alopecia hair growth dermal papilla cells DPCs apoptosis hair follicles dermis miR-22 TNF-α Wnt/β-catenin signaling pathway stem cell exosomes immune-related hair loss hair regrowth skin cells cell death skin layer microRNA-22 tumor necrosis factor-alpha Wnt signaling
![Image of study](/images/research/37575674-797c-4419-a8af-8492bc44edde/medium/5595.jpg)
TLDR Exosomes from fat-derived stem cells can potentially improve hair growth and could be a new treatment for immune-related hair loss.
The study investigated the effects of exosomes from adipose-derived stem cells (ADSC-Exos) on hair growth, particularly in immune-mediated alopecia. In vitro, ADSC-Exos promoted the proliferation and migration of dermal papilla cells (DPCs) and reduced apoptosis. In vivo, using a C57BL/6 hair-depilated mouse model, ADSC-Exos-treated mice showed improved hair growth, more hair follicles, and a thicker dermis compared to the control group. The study also found that the miR-22 and TNF-α signaling pathways were significantly downregulated in DPCs after ADSC-Exos treatment, and the Wnt/β-catenin signaling pathway was activated in the skin of ADSC-Exos-treated mice. The study concluded that ADSC-Exos therapy positively affected hair regrowth by regulating these pathways, suggesting that ADSC-Exos could be a promising cell-free therapeutic strategy for immune-mediated alopecia.