A Scoping Review of Exosome Delivery Applications in Hair Loss

This scoping review examines 16 studies on exosome delivery methods for treating non-cicatricial alopecia, particularly androgenetic alopecia and alopecia areata. The studies primarily used exosomes derived from mesenchymal stem cells and explored various delivery methods, with microneedle patches emerging as the most effective for targeted delivery. Exosome therapy shows promise in promoting hair follicle regeneration and enhancing hair growth by activating specific pathways. However, challenges such as the lack of standardization in exosome isolation and the need for further research to establish safety and efficacy remain, as no exosome products for alopecia are currently FDA-approved. The review suggests that exosome delivery methods could complement existing alopecia treatments, offering a novel approach to hair loss therapy.