Exosome Therapy in Hair Regeneration: A Literature Review of the Evidence, Challenges, and Future Opportunities

    April 2022 in “ Journal of cosmetic dermatology ”
    Yana Kost, Ahava Muskat, Nour Mhaimeed … Kseniya Kobets
    Studysummary This review found that while preclinical studies highlight the potential benefits of exosome therapeutics for hair loss, clinical evidence on their safety and effectiveness for alopecia is currently lacking, requiring further research.
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    Research cited in this study 23

    1. Exosomes Secreted from Adipose-Derived Stem Cells Are a Potential Treatment Agent for Immune-Mediated Alopecia Journal of immunology research · 2022
    2. Dermal Papilla Cell-Derived Extracellular Vesicles Increase Hair Inductive Gene Expression in Adipose Stem Cells via β-Catenin Activation Cells · 2022
    3. Hair Grows Hair: Dual-Effective Hair Regrowth Through a Hair Enhanced Dissolvable Microneedle Patch Cooperated with Pure Yellow Light Irradiation Applied materials today · 2021
    4. Effects of Adipose-Derived Stem Cells and Platelet-Rich Plasma Exosomes on the Inductivity of Hair Dermal Papilla Cells PubMed · 2021
    5. Platelet-Rich Plasma and Cell Therapy Dermatologic clinics · 2021
    6. Exosomes And Stem Cells 2021
    7. Regenerative Medicine and Hair Loss: To Exosome or Not to Exosome Hair transplant forum international · 2020
    8. Dermal Exosomes Containing miR-218-5p Promote Hair Regeneration by Regulating β-Catenin Signaling Science Advances · 2020
    9. Current Advances in Stem Cell-Based Therapies for Hair Regeneration European Journal of Pharmacology · 2020
    10. Macrophage-Derived Extracellular Vesicle Promotes Hair Growth Cells · 2020
    11. Sustained Release of Dermal Papilla-Derived Extracellular Vesicles from Injectable Microgel Promotes Hair Growth Theranostics · 2020
    12. Maintaining Hair Inductivity in Human Dermal Papilla Cells: A Review of Effective Methods Skin Pharmacology and Physiology · 2020
    13. Exosomes: A New Effective Non-Surgical Therapy for Androgenetic Alopecia? Skinmed · 2020
    14. Exosome for Hair Regeneration: From Bench to Bedside Journal of the American Academy of Dermatology · 2019
    15. Beta-Catenin-Mediated Hair Growth Induction Effect of 3,4,5-Tri-O-Caffeoylquinic Acid Aging · 2019
    16. Extracellular Vesicles from Activated Dermal Fibroblasts Stimulate Hair Follicle Growth Through Dermal Papilla-Secreted Norrin Stem cells · 2019
    17. A Therapeutic Microneedle Patch Made from Hair-Derived Keratin for Promoting Hair Regrowth ACS nano · 2019
    18. Exosomes Derived from Human Dermal Papilla Cells Promote Hair Growth in Cultured Human Hair Follicles and Augment the Hair-Inductive Capacity of Cultured Dermal Papilla Spheres Experimental Dermatology · 2019
    19. Exosomal MicroRNAs Derived from Dermal Papilla Cells Mediate Hair Follicle Stem Cell Proliferation and Differentiation International journal of biological sciences · 2019
    20. Platelet-Rich Plasma for Androgenetic Alopecia: A Review of the Literature and Proposed Treatment Protocol International Journal of Women's Dermatology · 2018
    21. Immunoregulatory Effects of Myeloid-Derived Suppressor Cell Exosomes in Mouse Model of Autoimmune Alopecia Areata Frontiers in immunology · 2018
    22. Regulation of Hair Follicle Development by Exosomes Derived from Dermal Papilla Cells Biochemical and Biophysical Research Communications · 2018
    23. The Hair Follicle Enigma Experimental Dermatology · 2017