Exosome Therapy in Hair Regeneration: A Literature Review of the Evidence, Challenges, and Future Opportunities

April 2022 in “ Journal of cosmetic dermatology ”

Yana Kost, Ahava Muskat, Nour Mhaimeed, Roya Nazarian, Kseniya Kobets

exosome therapy alopecia hair morphogenesis hair regeneration preclinical studies clinical trials exosome sources optimal delivery methods

TLDR Exosome therapy could help with hair loss, but more research is needed to confirm its safety and effectiveness.

This literature review explores the potential of exosome therapy as a treatment for alopecia, highlighting its role in hair morphogenesis and regeneration. The review includes 47 studies and discusses the history, mechanisms, and current clinical studies related to exosome use in medicine. While preclinical studies show promising benefits for hair loss treatment, clinical trials have yet to provide conclusive evidence of efficacy and safety for alopecia. The review identifies several gaps in knowledge, such as safety concerns, exosome sources, and optimal delivery methods, emphasizing the need for further research and clinical trials to establish exosome therapy as a viable treatment for hair loss.

View this study on onlinelibrary.wiley.com →

Discuss this study in the Community →

Research cited in this study

22 / 22 results

research Exosomes Secreted from Adipose-Derived Stem Cells Are a Potential Treatment Agent for Immune-Mediated Alopecia

6 citations , February 2022 in “Journal of immunology research”

Exosomes from fat-derived stem cells can potentially improve hair growth and could be a new treatment for immune-related hair loss.

research Dermal Papilla Cell-Derived Extracellular Vesicles Increase Hair Inductive Gene Expression in Adipose Stem Cells via β-Catenin Activation

12 citations , January 2022 in “Cells”

Dermal papilla cell vesicles can boost hair growth genes in fat stem cells.

research Hair Grows Hair: Dual-Effective Hair Regrowth Through a Hair Enhanced Dissolvable Microneedle Patch Cooperated with Pure Yellow Light Irradiation

20 citations , October 2021 in “Applied materials today”

A new microneedle patch and yellow light therapy significantly promote hair regrowth.

research Effects of Adipose-Derived Stem Cells and Platelet-Rich Plasma Exosomes on the Inductivity of Hair Dermal Papilla Cells

5 citations , October 2021 in “PubMed”

Exosomes from human fat stem cells can potentially enhance hair growth and survival, providing a new possible treatment for hair loss.

research Platelet-Rich Plasma and Cell Therapy

11 citations , May 2021 in “Dermatologic clinics”

PRP and cell therapies may help with hair loss, but more research is needed.

research Regenerative Medicine and Hair Loss: To Exosome or Not to Exosome

2 citations , November 2020 in “Hair transplant forum international”

Exosomes might be a promising new treatment for hair loss.

research Dermal Exosomes Containing miR-218-5p Promote Hair Regeneration by Regulating β-Catenin Signaling

65 citations , July 2020 in “Science Advances”

Dermal exosomes with miR-218-5p boost hair growth by controlling β-catenin signaling.

research Current Advances in Stem Cell-Based Therapies for Hair Regeneration

32 citations , May 2020 in “European Journal of Pharmacology”

Stem cell therapies show promise for hair regrowth but face production and application challenges.

research Macrophage-Derived Extracellular Vesicle Promotes Hair Growth

51 citations , April 2020 in “Cells”

Special cell particles from macrophages can help hair grow.

research Exosomes: A New Effective Non-Surgical Therapy for Androgenetic Alopecia?

1 citations , March 2020 in “Skinmed”

Exosome therapy shows promise for hair growth without side effects but needs more testing.

research Maintaining Hair Inductivity in Human Dermal Papilla Cells: A Review of Effective Methods

35 citations , January 2020 in “Skin Pharmacology and Physiology”

The review concluded that keeping the hair-growing ability of human dermal papilla cells is key for hair development and growth.

research Sustained Release of Dermal Papilla-Derived Extracellular Vesicles from Injectable Microgel Promotes Hair Growth

46 citations , January 2020 in “Theranostics”

Injecting a special gel with human protein particles can help hair grow.

research Exosome for Hair Regeneration: From Bench to Bedside

9 citations , August 2019 in “Journal of the American Academy of Dermatology”

Exosomes from stem cells may help treat hair loss.

research Beta-Catenin-Mediated Hair Growth Induction Effect of 3,4,5-Tri-O-Caffeoylquinic Acid

42 citations , June 2019 in “Aging”

3,4,5-tri-O-caffeoylquinic acid promotes hair growth by activating the β-catenin pathway.

research Extracellular Vesicles from Activated Dermal Fibroblasts Stimulate Hair Follicle Growth Through Dermal Papilla-Secreted Norrin

37 citations , June 2019 in “Stem cells”

Special particles from skin cells can promote hair growth by activating a specific growth signal.

research A Therapeutic Microneedle Patch Made from Hair-Derived Keratin for Promoting Hair Regrowth

192 citations , April 2019 in “ACS nano”

A new microneedle patch made from hair proteins helps regrow hair faster and better than current treatments.

Exosomes Derived from Human Dermal Papilla Cells Promote Hair Growth in Cultured Human Hair Follicles and Augment the Hair-Inductive Capacity of Cultured Dermal Papilla Spheres

research Exosomes Derived from Human Dermal Papilla Cells Promote Hair Growth in Cultured Human Hair Follicles and Augment the Hair-Inductive Capacity of Cultured Dermal Papilla Spheres

58 citations , March 2019 in “Experimental Dermatology”

Exosomes from human skin cells can stimulate hair growth and could potentially be used for treating hair loss.

research Exosomal MicroRNAs Derived from Dermal Papilla Cells Mediate Hair Follicle Stem Cell Proliferation and Differentiation

71 citations , January 2019 in “International journal of biological sciences”

Exosomes from dermal papilla cells help hair growth by making hair follicle stem cells multiply and change.

research Platelet-Rich Plasma for Androgenetic Alopecia: A Review of the Literature and Proposed Treatment Protocol

45 citations , September 2018 in “International Journal of Women's Dermatology”

PRP shows promise for hair loss treatment, with three initial monthly injections and maintenance every 3-6 months.

research Immunoregulatory Effects of Myeloid-Derived Suppressor Cell Exosomes in Mouse Model of Autoimmune Alopecia Areata

45 citations , June 2018 in “Frontiers in immunology”

MDSC-Exo can treat autoimmune alopecia areata and promote hair regrowth in mice.

research Regulation of Hair Follicle Development by Exosomes Derived from Dermal Papilla Cells

87 citations , April 2018 in “Biochemical and Biophysical Research Communications”

Exosomes from dermal papilla cells can help grow hair and might treat hair loss.

research The Hair Follicle Enigma

25 citations , March 2017 in “Experimental Dermatology”

The document concludes that understanding hair follicles requires more research using computational methods and an integrative approach, considering the current limitations in hair treatment products.

Similar Research

5 / 760 results

research Clinical And Preclinical Approach In AGA Treatment: A Review Of Current And New Therapies In The Regenerative Field

August 2024 in “Stem Cell Research & Therapy”

New regenerative therapies show promise for treating hair loss.

research Exosome Therapy in Hair Regeneration: A Literature Review of the Evidence, Challenges, and Future Opportunities

July 2022 in “The journal of investigative dermatology/Journal of investigative dermatology”

Exosome therapy shows promise for hair loss but needs more research on safety and effectiveness.

Adipose-Derived Stem Cell Exosomes Antagonize the Inhibitory Effect of Dihydrotestosterone on Hair Follicle Growth by Activating Wnt/Beta-Catenin Pathway

research Adipose-Derived Stem Cell Exosomes Antagonize the Inhibitory Effect of Dihydrotestosterone on Hair Follicle Growth by Activating Wnt/Beta-Catenin Pathway

September 2023 in “Stem Cells International”

Substances from fat-derived stem cells can promote hair growth and counteract hormone-related hair loss by activating a key hair growth pathway.

research Pathophysiological Mechanisms of Hair Follicle Regeneration and Potential Therapeutic Strategies

June 2025 in “Stem Cell Research & Therapy”

Understanding hair growth pathways can lead to better hair loss treatments.

research Potential of Colostrum-Derived Exosomes for Promoting Hair Regeneration Through the Transition from Telogen to Anagen Phase

5 citations , March 2022 in “Frontiers in Cell and Developmental Biology”

Colostrum-derived exosomes can promote hair growth and may be a promising treatment for hair loss.