Pathophysiological Mechanisms of Hair Follicle Regeneration and Potential Therapeutic Strategies

    June 2025 in “ Stem Cell Research & Therapy
    Depti Bellani, Rasika J Patil, Ashwin Prabhughate, Riya Shahare, Michael H. Gold, Rinky Kapoor, Debraj Shome
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    TLDR Understanding hair growth pathways can lead to better hair loss treatments.
    The document reviews the pathophysiological mechanisms of hair follicle regeneration, focusing on androgenetic alopecia (AGA) and other hair loss conditions. It highlights key molecular pathways, such as Wnt/β-catenin, Sonic Hedgehog (Shh), Notch, and Bone Morphogenetic Protein (BMP), which are crucial for hair follicle cycling and regeneration. Dysregulation of these pathways can lead to hair loss, and therapeutic strategies targeting them, including small molecules, gene therapy, and biologics, are being explored. The review emphasizes the importance of understanding these signaling networks to develop precise and durable therapies for alopecia, while also considering potential adverse effects. Integrating traditional therapies with pathway-targeted approaches and personalized treatment strategies may enhance treatment outcomes.
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