The Balance of BMP6 and WNT10B Regulates the Telogen-Anagen Transition of Hair Follicles

    February 2019 in “ Cell Communication and Signaling ”
    Pan Wu, Yiming Zhang, Yizhan Xing … Yuhong Li
    Studysummary This study found that BMP6 and Wnt10b competitively regulate the transition between hair follicle growth phases, offering new insights into hair follicle cycling and potential hair loss treatments.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
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    Research cited in this study 9

    1. Immunohistochemical Study of Hair Follicle Stem Cells in Regenerated Hair Follicles Induced by Wnt10b International Journal of Medical Sciences · 2016
    2. An Integrated Transcriptome Atlas of Embryonic Hair Follicle Progenitors, Their Niche, and the Developing Skin Developmental cell · 2015
    3. Competitive Balance of Intrabulge BMP/Wnt Signaling Reveals a Robust Gene Network Ruling Stem Cell Homeostasis and Cyclic Activation Proceedings of the National Academy of Sciences · 2013
    4. Adenovirus-Mediated Wnt10b Overexpression Induces Hair Follicle Regeneration Journal of Investigative Dermatology · 2012
    5. Multi-Layered Environmental Regulation on the Homeostasis of Stem Cells: The Saga of Hair Growth and Alopecia Journal of Dermatological Science · 2012
    6. Paracrine TGF-β Signaling Counterbalances BMP-Mediated Repression in Hair Follicle Stem Cell Activation Cell stem cell · 2012
    7. Dynamic Signals for Hair Follicle Development and Regeneration Stem Cells and Development · 2011
    8. Self-Organizing and Stochastic Behaviors During the Regeneration of Hair Stem Cells Science · 2011
    9. Defining BMP Functions in the Hair Follicle by Conditional Ablation of BMP Receptor IA The Journal of Cell Biology · 2003

    Related research 4

    1. Hair Follicle Expression of 1,25-Dihydroxyvitamin D3 Receptors During the Murine Hair Cycle British Journal of Dermatology · 2006
    2. Contrasting Localization of c-Myc with Other Myc Superfamily Transcription Factors in the Human Hair Follicle and During the Hair Growth Cycle ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2001
    3. Expression of E6 and E7 Papillomavirus Oncogenes in the Outer Root Sheath of Hair Follicles Extends the Growth Phase and Bypasses Resting at Telogen PubMed · 2000
    4. Angora Mouse Mutation: Altered Hair Cycle, Follicular Dystrophy, Phenotypic Maintenance of Skin Grafts, and Changes in Keratin Expression Veterinary Pathology · 1997