Signaling Pathways in Hair Aging

    November 2023 in “ Frontiers in cell and developmental biology ”
    Aiye Liang, Yuqiang Fang, Lan Ye … Xuejuan Xu
    Studysummary This source reviews mechanisms and existing treatments for hair aging, highlighting factors like oxidative stress and DNA repair defects that affect hair follicle and stem cell function, and discusses research limitations and future directions in the field.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
    Read the full study on frontiersin.org →
    Discuss this study in the Community →

    Research cited in this study 90

    1. Estetrol Prolongs Anagen in Healthy Female Scalp Hair Follicles by Positively Modulating Dermal Papilla Functions and Generation of Progenitor Stem Cells Ex Vivo Journal of the Endocrine Society · 2023
    2. IPSC-Based Approach for Human Hair Follicle Regeneration Frontiers in Cell and Developmental Biology · 2023
    3. Baricitinib for the Treatment of Alopecia Areata Drugs · 2023
    4. Androgenetic Alopecia: Therapy Update Drugs · 2023
    5. Injury-Induced Interleukin-1 Alpha Promotes Lgr5 Hair Follicle Stem Cells Regeneration and Proliferation via Regulating Regenerative Microenvironment in Mice Inflammation and Regeneration · 2023
    6. Effects of Hormones and Endocrine Disorders on Hair Growth Cureus · 2022
    7. Regenerative Medicine Strategies for Hair Growth and Regeneration: A Narrative Review of Literature Regenerative Therapy · 2022
    8. Stem Cell Secretome as a Mechanism for Restoring Hair Loss Due to Stress, Particularly Alopecia Areata: Narrative Review Journal of Biomedical Science · 2022
    9. Innate Type 2 Immunity Controls Hair Follicle Commensalism by Demodex Mites Immunity · 2022
    10. Aging in the Sebaceous Gland Frontiers in Cell and Developmental Biology · 2022
    11. PBX1-SIRT1 Positive Feedback Loop Attenuates ROS-Mediated HF-MSC Senescence and Apoptosis Stem cell reviews and reports · 2022
    12. Generation And Characterization Of Hair-Bearing Skin Organoids From Human Pluripotent Stem Cells Nature Protocols · 2022
    13. Treatment of Androgenetic Alopecia Using PRP to Target Dysregulated Mechanisms and Pathways Frontiers in Medicine · 2022
    14. Cyanidin 3-O-Arabinoside Suppresses DHT-Induced Dermal Papilla Cell Senescence by Modulating p38-Dependent ER-Mitochondria Contacts Journal of Biomedical Science · 2022
    15. Topical Finasteride for Male and Female Pattern Hair Loss: Is It a Safe and Effective Alternative? Journal of Cosmetic Dermatology · 2022
    16. Androgen Receptor-Mediated Paracrine Signaling Induces Regression of Blood Vessels in the Dermal Papilla in Androgenetic Alopecia Journal of Investigative Dermatology · 2022
    17. Intrinsic ROS Drive Hair Follicle Cycle Progression by Modulating DNA Damage and Repair and Subsequently Hair Follicle Apoptosis and Macrophage Polarization Oxidative Medicine and Cellular Longevity · 2022
    18. Female Pattern Hair Loss Springer eBooks · 2022
    19. The JAK/STAT Signaling Pathway: From Bench to Clinic Signal Transduction and Targeted Therapy · 2021
    20. Editorial: Hair Follicle Stem Cell Regeneration in Aging Frontiers in Cell and Developmental Biology · 2021
    21. PBX1 Attenuates Hair Follicle-Derived Mesenchymal Stem Cell Senescence and Apoptosis by Alleviating Reactive Oxygen Species-Mediated DNA Damage Instead of Enhancing DNA Damage Repair Frontiers in Cell and Developmental Biology · 2021
    22. Generation of Skin Organoids: Potential Opportunities and Challenges Frontiers in cell and developmental biology · 2021
    23. A Systematic Review and Meta-Analysis of Randomized Controlled Trials of United States Food and Drug Administration-Approved, Home-Use, Low-Level Light/Laser Therapy Devices for Pattern Hair Loss: Device Design and Technology PubMed · 2021
    24. Emerging Role of Dermal White Adipose Tissue in Modulating Hair Follicle Development During Aging Frontiers in Cell and Developmental Biology · 2021
    25. Hair Growth-Promotion Effects at the Cellular Level and Antioxidant Activity of the Plant-Based Extract Phyllotex Heliyon · 2021
    26. A Systematic Summary of Survival and Death Signaling During the Life of Hair Follicle Stem Cells Stem Cell Research & Therapy · 2021
    27. Minoxidil: A Comprehensive Review Journal of Dermatological Treatment · 2021
    28. Argan (Argania Spinosa) Press Cake Extract Enhances Cell Proliferation and Prevents Oxidative Stress and Inflammation of Human Dermal Papilla Cells Journal of dermatological science · 2021
    29. Effects of UV-Induced Photoaging on the Hair Follicle Cycle of C57BL6/J Mice Clinical, cosmetic and investigational dermatology · 2021
    30. Corticosterone Inhibits GAS6 to Govern Hair Follicle Stem-Cell Quiescence Nature · 2021
    31. Telomere Dynamics and Telomerase in the Biology of Hair Follicles and Their Stem Cells as a Model for Aging Research Journal of Investigative Dermatology · 2021
    32. Role of Low-Level Light Therapy in Androgenetic Alopecia Journal of Cutaneous and Aesthetic Surgery · 2021
    33. Platelet-Rich Plasma: New Performance Understandings and Therapeutic Considerations in 2020 International Journal of Molecular Sciences · 2020
    34. The biology of human hair greying Biological reviews/Biological reviews of the Cambridge Philosophical Society · 2020
    35. Novel 'After Minoxidil' Spray Improves Topical Minoxidil Compliance and Hair Style Manageability Journal of Cosmetic Dermatology · 2020
    36. Cell Types Promoting Goosebumps Form a Niche to Regulate Hair Follicle Stem Cells Cell · 2020
    37. Targeting Wnt/β-Catenin Pathway for Developing Therapies for Hair Loss International Journal of Molecular Sciences · 2020
    38. Hair-Bearing Human Skin Generated Entirely From Pluripotent Stem Cells Nature · 2020
    39. Getting Under the Skin of Hair Aging: The Impact of the Hair Follicle Environment Experimental Dermatology · 2020
    40. Dihydrotestosterone Regulates Hair Growth Through the Wnt/β-Catenin Pathway in C57BL/6 Mice and In Vitro Organ Culture Frontiers in Pharmacology · 2020
    41. Hyperactivation of Sympathetic Nerves Drives Depletion of Melanocyte Stem Cells Nature · 2020
    42. Advances in Stem Cell-Based Therapy for Hair Loss PubMed · 2020
    43. Inhibition of JAK-STAT Signaling with Baricitinib Reduces Inflammation and Improves Cellular Homeostasis in Progeria Cells Cells · 2019
    44. Telomere Dysfunction Impairs Epidermal Stem Cell Specification and Differentiation by Disrupting BMP/pSmad/P63 Signaling PLOS genetics · 2019
    45. Lymphatic Vessels Interact Dynamically with the Hair Follicle Stem Cell Niche During Skin Regeneration In Vivo The EMBO Journal · 2019
    46. Priming Mobilization of Hair Follicle Stem Cells Triggers Permanent Loss of Regeneration After Alkylating Chemotherapy Nature Communications · 2019
    47. PBX Homeobox 1 Enhances Hair Follicle Mesenchymal Stem Cell Proliferation and Reprogramming Through Activation of the AKT/Glycogen Synthase Kinase Signaling Pathway and Suppression of Apoptosis Stem Cell Research & Therapy · 2019
    48. Identification of the Sulfotransferase Iso-Enzyme Primarily Responsible for the Bio-Activation of Topical Minoxidil PubMed · 2019
    49. Cholesterol Homeostasis: Links to Hair Follicle Biology and Hair Disorders Experimental Dermatology · 2019
    50. The Role of the Microbiome in Scalp Hair Follicle Biology and Disease Experimental Dermatology · 2019
    51. A Subset of TREM2+ Dermal Macrophages Secretes Oncostatin M to Maintain Hair Follicle Stem Cell Quiescence and Inhibit Hair Growth Cell Stem Cell · 2019
    52. The Mechanism of Activated Platelet-Rich Plasma Supernatant Promotion of Hair Growth by Cultured Dermal Papilla Cells Journal of Cosmetic Dermatology · 2019
    53. Platelet-Rich Plasma for Androgenetic Alopecia: A Review of the Literature and Proposed Treatment Protocol International Journal of Women's Dermatology · 2018
    54. Inhibition of Glycosphingolipid Synthesis Reverses Skin Inflammation and Hair Loss in ApoE−/− Mice Fed Western Diet Scientific Reports · 2018
    55. A Systematic Review of Topical Finasteride in the Treatment of Androgenetic Alopecia in Men and Women PubMed · 2018
    56. Prostaglandin D2-Mediated DP2 and AKT Signal Regulate the Activation of Androgen Receptors in Human Dermal Papilla Cells International Journal of Molecular Sciences · 2018
    57. Three Streams for the Mechanism of Hair Graying Annals of dermatology/Annals of Dermatology · 2018
    58. Androgens and Androgen Receptor Action in Skin and Hair Follicles Molecular and Cellular Endocrinology · 2017
    59. Platelet-Rich Plasma—An 'Elixir' for Treatment of Alopecia: Personal Experience on 117 Patients with Review of Literature Stem cell investigation · 2017
    60. Aging in Hair Follicle Stem Cells and Niche Microenvironment The Journal of Dermatology · 2017
    61. Gata6 Promotes Hair Follicle Progenitor Cell Renewal by Genome Maintenance During Proliferation The EMBO Journal · 2016
    62. Hair Follicle Aging Is Driven by Transepidermal Elimination of Stem Cells via COL17A1 Proteolysis Science · 2016
    63. Pharmacologic Inhibition of JAK-STAT Signaling Promotes Hair Growth Science Advances · 2015
    64. Reversal of Alopecia Areata Following Treatment With the JAK1/2 Inhibitor Baricitinib EBioMedicine · 2015
    65. Macrophages Contribute to the Cyclic Activation of Adult Hair Follicle Stem Cells PLoS Biology · 2014
    66. Association of Premature Hair Graying with Family History, Smoking, and Obesity: A Cross-Sectional Study Journal of The American Academy of Dermatology · 2014
    67. Neuroendocrinology of the Hair Follicle: Principles and Clinical Perspectives Trends in Molecular Medicine · 2014
    68. Novel Enzymatic Assay Predicts Minoxidil Response in the Treatment of Androgenetic Alopecia Dermatologic Therapy · 2013
    69. Cause of Androgenic Alopecia Plastic and reconstructive surgery. Global open · 2013
    70. Age-Induced Hair Greying: The Multiple Effects of Oxidative Stress International Journal of Cosmetic Science · 2013
    71. Chronic Restraint Stress Inhibits Hair Growth via Substance P Mediated by Reactive Oxygen Species in Mice PLoS ONE · 2013
    72. Competitive Balance of Intrabulge BMP/Wnt Signaling Reveals a Robust Gene Network Ruling Stem Cell Homeostasis and Cyclic Activation Proceedings of the National Academy of Sciences · 2013
    73. Estrogen Leads to Reversible Hair Cycle Retardation Through Inducing Premature Catagen and Maintaining Telogen PLOS ONE · 2012
    74. Prostaglandin D2 Inhibits Hair Growth and Is Elevated in Bald Scalp of Men with Androgenetic Alopecia Science Translational Medicine · 2012
    75. Finasteride and Sexual Side Effects Indian Dermatology Online Journal · 2012
    76. Aging Processes Influence Keratin and KAP Expression in Human Hair Follicles Experimental Dermatology · 2011
    77. Clock Genes, Hair Growth, and Aging Aging · 2010
    78. Oxidative Stress in Aging of Hair International Journal of Trichology · 2009
    79. Towards A Free Radical Theory Of Graying: Melanocyte Apoptosis In The Aging Human Hair Follicle As An Indicator Of Oxidative Stress Induced Tissue Damage ˜The œFASEB journal · 2006
    80. Pharmacologic Interventions in Aging Hair Clinical Interventions in Aging · 2006
    81. The Hair Cycle Journal of Cell Science · 2006
    82. The Hair Cycle Journal of Cell Science · 2006
    83. Aging of Hair Journal of Cosmetic Dermatology · 2005
    84. Hair Cycle and Hair Pigmentation: Dynamic Interactions and Changes Associated with Aging Micron · 2003
    85. Allergic Contact Dermatitis to Topical Minoxidil Solution: Etiology and Treatment Journal of The American Academy of Dermatology · 2002
    86. Towards a Molecular Understanding of Hair Loss and Its Treatment Trends in Molecular Medicine · 2001
    87. Hair Loss in Psychopharmacology Annals of Clinical Psychiatry · 2000
    88. Lipid Peroxides Induce Early Onset of Catagen Phase in Murine Hair Cycles International Journal of Molecular Medicine · 1998
    89. Finasteride The New England Journal of Medicine · 1994
    90. Minoxidil: A Review of Its Pharmacological Properties and Therapeutic Use Drugs · 1981