Editorial: Hair Follicle Stem Cell Regeneration in Aging

November 2021 in “ Frontiers in Cell and Developmental Biology ”

Mingxing Lei, Sung‐Jan Lin, Cheng‐Ming Chuong

hair follicle stem cell hair loss graying quiescent state skin epithelial lineages hair follicle niche UVA Vitamin A inflammation dermal papilla in vitro culture models stem cell exhaustion cellular senescence intercellular communication skin cells UV light retinol lab-grown hair

TLDR Aging causes hair loss and graying due to stem cell decline and changes in cell behavior and communication.

The document discusses the decline in hair follicle stem cell regeneration with aging, leading to hair loss and graying. It explains that these cells either enter a long quiescent state, differentiate into other skin epithelial lineages, or escape from the hair follicle niche during aging. The role of intrinsic and extrinsic factors, including UVA, Vitamin A, inflammation, and the dermal papilla, in regulating these changes is highlighted. The potential of in vitro culture models in restoring hair regeneration is also discussed. The document concludes that factors such as stem cell exhaustion, cellular senescence, and altered intercellular communication contribute to aging-related hair loss and graying. The authors hope that this understanding will inspire new therapeutic strategies for treating aging-related hair disorders.

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