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    Glossaryhair follicle niche

    specialized skin microenvironment regulating hair growth and regeneration

    The hair follicle niche is a specialized microenvironment within the skin where hair follicles reside. It contains various cells, signaling molecules, and extracellular matrix components that work together to regulate hair growth, cycling, and regeneration. This niche plays a crucial role in maintaining the health and function of hair follicles, and disruptions in this environment can lead to conditions like alopecia.

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      learn Rapamycin

      mTOR regulator and immunosuppressant used more recently for anti-aging and hair regrowth

      learn Stemoxydine

      chemical from L'Oreal that encourages hair to enter growth phase

      learn Latanoprost

      glaucoma medication with hair follicle stimulant effects

      learn Valproic acid

      an anticonvulsant repurposed for hair loss via histone inhibition

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      community A concise, easy-to-understand post on Androgenic Alopecia theory and its practical applications

      in Research/Science  92 upvotes 2 years ago
      The mechanism of Androgenic Alopecia and practical applications of treatments like Minoxidil, Finasteride, RU58841, dermarolling, scalp massages, anti-fungals, progesterone, estrogen, PPAR-γ activators, reducing oxidative stress, and scalp exercises. It explains why DHT is important in AA and how other factors might be involved such as hypoxia, increased DKK-1 expression, morphological changes to the scalp, skull growth during childhood/puberty, and blood flow.

      community New Treatments, and a Huge Group Buy with Lots of Research

      in Research/Science  109 upvotes 1 year ago
      A user is organizing a group buy for various compounds aimed at reversing hair loss and gray hair, and improving brain health and fat loss. The user has developed a treatment plan based on extensive research and is inviting others to participate, with the option to choose only the compounds they need.

      community Verteporfin and Microneedling

      in Treatments 5 months ago
      Clinical studies by Dr. Barghouthi and Dr. Bloxham indicate that Verteporfin, when used with FUE and FUT hair transplantation methods, shows promise in hair follicle regeneration and minimal scarring due to its ability to inhibit Yes-associated protein (YAP). Microneedling at depths of 3-3.5mm, combined with Verteporfin, could potentially reactivate dormant follicles, although the optimal dosage and application method are still under investigation. Concerns remain about the DHT sensitivity of regenerated follicles, highlighting the need for further research to optimize trauma levels and Verteporfin concentrations to achieve effective and scar-free hair regeneration.