PBX1 Attenuates Hair Follicle-Derived Mesenchymal Stem Cell Senescence and Apoptosis by Alleviating Reactive Oxygen Species-Mediated DNA Damage Instead of Enhancing DNA Damage Repair

    November 2021 in “ Frontiers in Cell and Developmental Biology ”
    Yuan Wang, Yutong Sui, Aobo Lian, Xing Han, Feilin Liu, Kuiyang Zuo, Mingsheng Liu, Weiyong Sun, Ziyu Wang, Zinan Liu, Fei Zou, Rifeng Lu, Minghua Jin, Hongzhi Du, Kan Xu, Xiaomei Liu, Jinyu Liu
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    TLDR PBX1 helps reduce aging and cell death in hair follicle stem cells by decreasing DNA damage, not by improving DNA repair.
    The study found that the transcription factor PBX1 reduces aging (senescence) and programmed cell death (apoptosis) in hair follicle-derived mesenchymal stem cells (HF-MSCs) by lessening DNA damage caused by reactive oxygen species (ROS), rather than by enhancing DNA repair. Overexpression of PBX1 significantly reduced ROS accumulation, cellular senescence, and apoptosis. Conversely, overexpression of PARP1, a protein involved in DNA repair, increased these factors. This suggests that PBX1 may be upstream of PARP1 in this process. These findings could contribute to strategies for alleviating tissue and organ aging, particularly in relation to hair regeneration.
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