TLDR PBX1 reduces aging and cell death in stem cells by boosting SIRT1 and lowering PARP1.
The study demonstrates that PBX1 overexpression reduces hair follicle-derived mesenchymal stem cell (HF-MSC) senescence and apoptosis by upregulating SIRT1 and downregulating PARP1, leading to increased NAD and ATP levels. Conversely, SIRT1 knockdown or PARP1 overexpression exacerbates senescence and apoptosis through increased ROS and DNA damage. PBX1 can counteract the negative effects of SIRT1 knockdown or PARP1 overexpression. The findings reveal a positive feedback loop between PBX1 and SIRT1, positioning PBX1 upstream of SIRT1, and highlight the PBX1-SIRT1-PARP1 axis as crucial in mitigating HF-MSC senescence and apoptosis, offering insights into stem cell aging and potential therapeutic strategies for age-related diseases.
9 citations,
November 2021 in “Frontiers in Cell and Developmental Biology” PBX1 helps reduce aging and cell death in hair follicle stem cells by decreasing DNA damage, not by improving DNA repair.
26 citations,
August 2019 in “Stem Cell Research & Therapy” PBX1 helps hair stem cells grow and change by turning on certain cell signals and preventing cell death, which may be useful for hair regrowth treatments.
106 citations,
October 2016 in “Cell Stem Cell” PDGFA/AKT signaling is important for the growth and maintenance of certain skin fat cells.
242 citations,
February 2016 in “Science” Hair loss and aging are caused by the breakdown of a key protein in hair stem cells.
135 citations,
December 2013 in “Seminars in Cell & Developmental Biology” Stem cells in the hair follicle are regulated by their surrounding environment, which is important for hair growth.
12 citations,
August 2022 in “Stem cell reviews and reports” Increasing PBX1 reduces aging and cell death in hair follicle stem cells by boosting SIRT1 and lowering PARP1 activity.
November 2023 in “Frontiers in cell and developmental biology” Hair aging is caused by stress, hormones, inflammation, and DNA damage affecting hair growth and color.
8 citations,
March 2015 in “Molecular Medicine Reports” Hair dye ingredient PPD causes cell death and aging in human hair cells by altering microRNA levels.
119 citations,
March 2020 in “Frontiers in Bioengineering and Biotechnology” Asia has made significant progress in tissue engineering and regenerative medicine, but wider clinical use requires more development.
7 citations,
January 2023 in “Journal of Hematology & Oncology” Using protein degradation to fight cancer drug resistance shows promise but needs more precise targeting and fewer side effects.
