TLDR Hair dye ingredient PPD causes cell death and aging in human hair cells by altering microRNA levels.
The study investigated the effects of para-phenylenediamine (PPD) on normal human hair dermal papilla cells, revealing that PPD induced cell death and senescence through the alteration of specific microRNAs (miRNAs). Key findings included G2 phase arrest, increased reactive oxygen species (ROS) production, and senescence-associated β-galactosidase activity. PPD treatment led to significant downregulation of miR-146b-5p and miR-378, which are involved in cell survival and anti-senescence. The study identified 74 miRNAs with altered expression due to PPD, implicating the Wnt and MAPK signaling pathways in hair growth and cell proliferation regulation. These results suggested potential miRNA targets for treating PPD-induced cellular dysfunction.
20 citations,
June 2011 in “ISRN Dermatology (Print)” A woman lost most of her hair due to an allergic reaction to a hair dye ingredient.
149 citations,
June 2010 in “The FASEB journal” miR-31 regulates hair growth by controlling gene expression in hair follicles.
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September 2005 in “Proceedings of the National Academy of Sciences of the United States of America” The HR protein helps hair grow by blocking a hair growth inhibitor, aiding in hair follicle regeneration.
76 citations,
August 2018 in “International Journal of Cosmetic Science” Dermal Papilla cells are a promising tool for evaluating hair growth treatments.
43 citations,
January 2013 in “Indian Journal of Dermatology, Venereology and Leprology” The article concludes that advancements in hair cosmetics require dermatologists to stay informed about products and their potential risks, including allergies and higher risks for hairdressers.
October 2023 in “International journal of women’s dermatology” Hair camouflage methods like wigs and extensions can help Black women with alopecia feel better but may also damage hair if not used carefully.
October 2001 in “WORLD SCIENTIFIC eBooks” Many substances, including chemicals and metals, can cause skin reactions; careful handling and identification of allergens are crucial to prevent dermatitis.
20 citations,
June 2011 in “ISRN Dermatology (Print)” A woman lost most of her hair due to an allergic reaction to a hair dye ingredient.
