Implication of MicroRNA Regulation in Para-Phenylenediamine-Induced Cell Death and Senescence in Normal Human Hair Dermal Papilla Cells

    March 2015 in “ Molecular Medicine Reports ”
    Ok‐Kyu Lee, Hwa Jun, Myung J. Lee, Kyung Mi Lim, Jin Tae Jung, Kyu Joong Ahn, In‐Sook An, Sungkwan An, Seunghee Bae
    TLDR Hair dye ingredient PPD causes cell death and aging in human hair cells by altering microRNA levels.
    The study investigated the effects of para-phenylenediamine (PPD) on normal human hair dermal papilla cells, revealing that PPD induced cell death and senescence through the alteration of specific microRNAs (miRNAs). Key findings included G2 phase arrest, increased reactive oxygen species (ROS) production, and senescence-associated β-galactosidase activity. PPD treatment led to significant downregulation of miR-146b-5p and miR-378, which are involved in cell survival and anti-senescence. The study identified 74 miRNAs with altered expression due to PPD, implicating the Wnt and MAPK signaling pathways in hair growth and cell proliferation regulation. These results suggested potential miRNA targets for treating PPD-induced cellular dysfunction.
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