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Glossary Paraphenylenediamine

chemical in hair dyes that can cause allergic reactions

Paraphenylenediamine (PPD) is a chemical commonly used in hair dyes to achieve long-lasting color. It is known for its ability to penetrate the hair shaft and provide a natural-looking color, but it can also cause allergic reactions in some individuals, leading to skin irritation or more severe responses.

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Research

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research Severe Hair Loss of the Scalp due to a Hair Dye Containing Para phenylenediamine

20 citations , June 2011 in “ISRN Dermatology (Print)”

This case report describes a woman experiencing severe hair loss due to allergic contact dermatitis from a hair dye containing PPD.

research Chemical Leukoderma from Hair Dye Containing para-Phenylenediamine

9 citations , July 2012 in “Dermatitis”

Hair dye with para-phenylenediamine can cause skin depigmentation.

research Implication of microRNA regulation in para-phenylenediamine-induced cell death and senescence in normal human hair dermal papilla cells

8 citations , March 2015 in “Molecular Medicine Reports”

This study found that para-phenylenediamine induces cytotoxic effects in normal human hair dermal papilla cells by altering microRNA expression and causing cell death, cell cycle arrest, and oxidative stress.

research Patch tests with commercial hair dye products in patients with allergic contact dermatitis to para-phenylenediamine

6 citations , January 2016 in “Indian Journal of Dermatology Venereology and Leprology”

This study found that the majority of "hypoallergenic" hair dyes still triggered allergic reactions in patients sensitive to para-phenylenediamine.

research Geranyl Acetate Attenuates Para-phenylenediamine-induced Cytotoxicity, DNA Damage, Apoptosis, and Inflammation in HaCaT Keratinocytes

1 citations , October 2025 in “Iranian journal of pharmaceutical research”

This study suggests that geranyl acetate may offer protective, anti-inflammatory, and cytoprotective effects against PPD-induced toxicity in keratinocyte cells, indicating its potential as a plant-derived treatment.

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community Mudei a Finasterida 1mg para Dutasterida 0,5mg

2 upvotes 3 weeks ago

The conversation discusses switching from finasteride 1mg to dutasteride 0.5mg due to thinning hair at the crown despite using finasteride and oral minoxidil. Another user mentions starting a combination pill with dutasteride, having previously used finasteride, minoxidil, and biotin.

community 5 meses usando Dut + min ... Transplante agendado para agosto 2027

8 upvotes 1 month ago

A user shared progress pictures after 5 months of using Dutasteride 0.5 mg and Minoxidil 2.5 mg, with a hair transplant planned for August 2027. Suggestions included increasing Minoxidil dosage and considering Finasteride if results are not satisfactory.

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