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    Did you mean Paraphenylenediamine?
    Glossary Paraphenylenediamine

    chemical in hair dyes that can cause allergic reactions

    Paraphenylenediamine (PPD) is a chemical commonly used in hair dyes to achieve long-lasting color. It is known for its ability to penetrate the hair shaft and provide a natural-looking color, but it can also cause allergic reactions in some individuals, leading to skin irritation or more severe responses.

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    1. Severe Hair Loss of the Scalp due to a Hair Dye Containing Para phenylenediamine ISRN Dermatology (Print) · 2011 · 20 citations
    2. Chemical Leukoderma from Hair Dye Containing para-Phenylenediamine Dermatitis · 2012 · 9 citations
    3. Implication of microRNA regulation in para-phenylenediamine-induced cell death and senescence in normal human hair dermal papilla cells Molecular Medicine Reports · 2015 · 8 citations
    4. Patch tests with commercial hair dye products in patients with allergic contact dermatitis to para-phenylenediamine Indian Journal of Dermatology Venereology and Leprology · 2016 · 6 citations
    5. Geranyl Acetate Attenuates Para-phenylenediamine-induced Cytotoxicity, DNA Damage, Apoptosis, and Inflammation in HaCaT Keratinocytes Iranian journal of pharmaceutical research · 2025 · 1 citations
    6. Paraphenylenediamine hair dyeing nephropathy: a case report and review of literature Urology & Nephrology Open Access Journal · 2018 · 4 citations
    7. A REVIEW ON COLOURFUL MEHENDI: THE RISK OF PARAPHENYLENEDIAMINE Journal of Biological and Scientific Opinion · 2019 · 1 citations
    8. P-Phenylenediamine-Induced Angioedema-like Facies: A Case Report and Review of Pathomechanisms Indian Dermatology Online Journal · 2026
    9. 55 cases of allergic reactions to hair dye: a descriptive, consumer complaint‐based study Contact Dermatitis · 2002 · 98 citations
    10. Hair cosmetics Indian Journal of Dermatology, Venereology and Leprology · 2013 · 43 citations
    11. Allergic contact dermatitis from dyes in wigs following diphencyprone treatment Contact dermatitis · 2004 · 8 citations
    12. 728 Chemical Burns and Eyebrow Tinting: An Unusual Case Journal of burn care & research · 2022 · 1 citations
    13. Sensitization and Clinically Relevant Allergy to Hair Dyes and Clothes from Black Henna Tattoos: Do People Know the Risk? An Uncommon Serious Case and a Review of the Literature Cosmetics · 2016 · 1 citations
    14. DERMATOLOGICAL AND SYSTEMIC REACTIONS TO HAIR DYES: CURRENT EVIDENCE AND MANAGEMENT International Journal of Applied Pharmaceutics · 2026
    15. Analysis of Patch Testing for Allergic Contact Dermatitis in Adults Versus Geriatrics: A 7-Year Retrospective Analysis of 342 Positive Patch Test Cases Indian Journal of Dermatology · 2026
    16. Patterns of Sensitization and Cross-Reactivity in Hair Dye Allergy: An 18-Year Tertiary-Center Experience from Greece. PubMed · 2026
    17. Allergic Contact Dermatitis Associated With Men’s Personal Care Products: A Review of Allergens Dermatitis · 2024
    18. Formulation and Evaluation of Herbal Hair Dye Zenodo (CERN European Organization for Nuclear Research) · 2022
    19. Apply directly to the forehead: Holmes, Nana, and hennapecia The FASEB Journal · 2007
    20. Effets indésirables des soins capillaires chez les utilisateurs Annales de dermatologie et de vénéréologie · 2018 · 11 citations
    21. Actualités réglementaires relatives aux produits cosmétiques Annales de Dermatologie et de Vénéréologie · 2007 · 4 citations
    22. NATURAL HAIR DYE POWDER “A SUSTAINABLE ALTERNATIVE TO SYNTHETIC DYES” 2026
    23. Journal Watch Clinical and Experimental Dermatology · 2001
    24. Effets indésirables des soins capillaires chez les utilisateurs. 2000
    25. A clinical evaluation of a permanent hair dye designed to reduce allergic contact dermatitis and hair damage Journal of Cosmetic Dermatology · 2022 · 9 citations
    26. Frontal fibrosing alopecia preceding the development of vitiligo: A case report JAAD case reports · 2020
    27. Allergic contact dermatitis of the scalp: a review of an underdiagnosed entity International Journal of Women’s Dermatology · 2024 · 5 citations
    28. An ultrastuctural study of hair fiber damage and restoration following treatment with permanent hair dye International Journal of Dermatology · 2002 · 40 citations
    29. Metal-Chelation-Assisted Deposition of Polydopamine on Human Hair: A Ready-to-Use Eumelanin-Based Hair Dyeing Methodology ACS biomaterials science & engineering · 2017 · 63 citations
    30. Enzymatic synthesis of biosafe hematoxylin dyes on hair: enhanced post-dyeing hair health and boosting color fastness International Journal of Biological Macromolecules · 2025