Allergens of Permanent Hair Dyes Induce Epidermal Damage, Skin Barrier Loss, and IL-1 Alpha Increase in Epidermal In Vitro Model

    December 2017 in “ Food and chemical toxicology ”
    Thalita B. Zanoni, Tatiana do Nascimento Pedrosa, Carolina Motter Catarino, Sander W. Spiekstra, Danielle Palma de Oliveira, G.J.M. den Hartog, Aalt Bast, Geja Hagemann, Susan Gibbs, Sílvia Berlanga de Moraes Barros, Silvya Stuchi Maria‐Engler
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    Studysummary This study found that mixtures used in permanent hair dyes had irritant effects on reconstructed human epidermis, while individual ingredients alone did not. Our plain-language summary of this paper — not a Tressless recommendation.
    The study investigated the effects of permanent hair dye ingredients on skin irritation using a reconstructed human epidermis (RhE) model. It was found that individual ingredients like p-phenylenediamine (PPD), Resorcinol (RES), and Hydrogen Peroxide (H2O2) did not cause significant cytotoxicity or skin irritation. However, when these ingredients were combined (PPD/H2O2/RES and PPD/H2O2), they induced morphological changes, barrier loss, and increased IL-1 α release, indicating an irritant effect. This suggests that the mixture of ingredients in permanent hair dyes can cause skin irritation, whereas the individual components alone do not.
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