Gene Expression Profiling of Human Keratinocytes Exposed to the Hair-Dyeing Agent, m-Aminophenol

March 2013 in “ Molecular & Cellular Toxicology/Molecular & cellular toxicology ”

So Young-jin, Chan-Young Shin, Mee Song, Jae‐Chun Ryu

m-aminophenol hair dye keratinocytes HaCaT cells gene expression inflammatory response oxidative stress TGF-beta signaling pathway reactive oxygen species cellular toxicity skin toxicity MAP skin cells ROS TGF-beta

Studysummary In this study, exposure to m-Aminophenol in human keratinocytes altered the expression of thousands of genes involved in inflammation and stress responses, suggesting potential biomarkers for MAP-induced skin toxicity. Our plain-language summary of this paper — not a Tressless recommendation.

The study investigated the effects of m-aminophenol (MAP), a common hair dye ingredient, on human keratinocytes (HaCaT cells) by analyzing changes in gene expression. Exposure to 1.2 mM MAP resulted in the up-regulation of 3,441 genes and down-regulation of 2,583 genes, with significant involvement in inflammatory and oxidative stress responses, as well as the TGF-beta signaling pathway. MAP exposure also induced reactive oxygen species (ROS) generation, contributing to cellular toxicity. The findings suggested that MAP-induced gene expression changes could serve as biomarkers for detecting skin toxicity, highlighting the potential risks associated with MAP in hair dyes.

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