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January 2014 in “Journal of Dermatology and Venereology”
The study investigated the effects of a botanical extract from a unique region in Turkey on gene expression in HaCaT human keratinocyte cells, which are relevant to hair loss. The extract demonstrated anti-inflammatory and anti-androgenic properties by downregulating IL-1α and 5-α-reductase gene expressions, respectively. Additionally, it upregulated VEGF gene expression, a significant growth-promoting factor. These findings suggested that the plant mix could be a promising candidate for preventing hair loss due to its beneficial properties.
NMN shows promise in promoting hair growth by reducing oxidative stress and weakening androgens. It may be a beneficial addition to hair loss treatments like Minoxidil and Finasteride.
PP405 is a promising molecule that may reactivate dormant hair follicles, potentially offering a new treatment for hair loss. It is in phase 2 trials, with possible availability between 2027 and 2030.
Finasteride can reduce neuroactive steroids, causing side effects like depression, anxiety, and sexual dysfunction. Some users experience persistent symptoms after stopping finasteride, while others use alternative treatments like topical solutions.
The treatment for androgenetic alopecia involves using finasteride and minoxidil with intense exercise and cold exposure to boost metabolism and reduce androgenic effects, potentially leading to hair regrowth. This approach may activate biological pathways for improved hair and overall health.
The conversation speculates on whether Tom Cruise uses hair loss treatments like Finasteride or Dutasteride, with some suggesting he naturally has good hair like Brad Pitt, while others joke about Scientology or genetics playing a role. Specific treatments mentioned include Finasteride, Dutasteride, and possibly high-quality hair products or procedures like PRP (Platelet-Rich Plasma).