Investigation of the Gene Expression Levels of 5 Alpha-Reductase, VEGF, and IL-1 Alpha in HaCaT Cells After the Application of a Botanical Extract

January 2014 in “ Journal of Dermatology and Venereology ”

Ahu Izgi, Murat Türkoğlu, Berrin Akyıldırım, Sabiha Çelen, Nuray Çelik

5 α-reductase VEGF IL-1α HaCaT cells botanical extract anti-inflammatory anti-androgenic gene expression keratinocyte vascular endothelial growth factor interleukin-1 alpha 5-alpha-reductase plant extract

TLDR The plant extract may help prevent hair loss by reducing inflammation and promoting hair growth.

The study investigated the effects of a botanical extract from a unique region in Turkey on gene expression in HaCaT human keratinocyte cells, which are relevant to hair loss. The extract demonstrated anti-inflammatory and anti-androgenic properties by downregulating IL-1α and 5-α-reductase gene expressions, respectively. Additionally, it upregulated VEGF gene expression, a significant growth-promoting factor. These findings suggested that the plant mix could be a promising candidate for preventing hair loss due to its beneficial properties.

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