The Effects of Rosmarinus Officinalis on VEGF and IL-1α Gene Expressions in HaCaT Cells: Unraveling Its Mechanism of Action in Wound Healing and Hair Loss

January 2026 in “ PubMed ”

Erkin Pekmezci, S Kılıç, H Sevinç, M Türkoğlu

Rosmarinus officinalis VEGF IL-1α HaCaT cells wound healing hair loss Rosemary

TLDR Rosemary may help with wound healing and hair growth by increasing VEGF.

The study investigates the effects of Rosmarinus officinalis (Ro) on VEGF and IL-1α gene expressions in HaCaT cells, focusing on its role in wound healing and hair loss. While the modulation of IL-1α was non-significant, there was a significant upregulation of VEGF, which may partially explain Ro's beneficial effects. The study suggests that further in-vitro and in-vivo research is necessary to understand the molecular mechanisms behind Ro's therapeutic effects and its potential applications in skin disorders.

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