The Effects of Rosmarinus Officinalis on VEGF and IL-1α Gene Expressions in HaCaT Cells: Unraveling Its Mechanism of Action in Wound Healing and Hair Loss

    January 2026 in “ PubMed ”
    Erkin Pekmezci, S Kılıç, H Sevinç, M Türkoğlu
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    Vascular Endothelial Growth Factor →
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    herb and oil with stimulant, circulatory, anti-inflammatory and antioxidant properties

    Studysummary This study reported a significant upregulation of VEGF, which may help explain the beneficial effects of Ro on wound healing and hair loss, although further in-vitro and in-vivo studies are needed to better understand its molecular mechanisms and potential applications for skin disorders.
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    The study investigates the effects of Rosmarinus officinalis (rosemary) on gene expressions related to wound healing and hair loss in HaCaT cells. The research found that treatment with rosemary extract significantly upregulated VEGF gene expression by 7.45±1.87 fold, which may contribute to its beneficial effects in wound healing and hair loss. However, the downregulation of IL-1α was not significant. These findings suggest that rosemary could have therapeutic potential, but further studies are needed to fully understand its mechanisms and applications in skin disorders.
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