A Comparative Study to Test a Plant Extract Against Minoxidil in HaCaT Cells

January 2017 in “ Journal of Dermatology and Venereology ”

Murat Türkoğlu, Cihat Dündar, Hakan Sevinç, Songül Kılıç

minoxidil botanical extract HaCaT cells interleukin-1α IL-1α stereoid-5α-reductase type 2 SRD5α2 hair loss Rogaine

TLDR The plant extract and minoxidil both reduce hair loss by lowering specific gene expressions.

In this study, the effects of a botanical extract and 1% minoxidil solution on HaCaT cells were compared to investigate their potential in treating hair loss. Both treatments significantly downregulated interleukin-1α (IL-1α) gene expression, with the botanical extract causing a five-fold decrease and minoxidil causing a three-fold decrease. While the botanical extract did not significantly affect stereoid-5α-reductase type 2 (SRD5α2) gene expression, minoxidil did result in its downregulation. The findings suggested that the anti-hair loss effect of minoxidil might be due to the suppression of IL-1α and SRD5α2 gene expressions.

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