Proprietary Herbal Extract Downregulates the Gene Expression of IL-1α in HaCaT Cells: Possible Implications Against Nonscarring Alopecia

    January 2018 in “ Medicinski arhiv ”
    Erkin Pekmezci, Cihat Dündar, Murat Türkoğlu
    Image of study
    TLDR A herbal extract may help treat certain types of hair loss by reducing a specific gene's activity.
    In the 2018 study by Pekmezci et al., a proprietary herbal extract (HE) composed of six different herbal extracts was tested on HaCaT cells (human keratinocytes) for its effects on IL-1α gene expression, a cytokine involved in nonscarring alopecia forms like androgenetic alopecia, telogen effluvium, and alopecia areata. The HE significantly downregulated IL-1α gene expression with a fold change of 0.1900 (p<0.0001), suggesting its potential as a supportive treatment for these alopecia types. The study also included a phytochemical analysis of the HE, identifying beneficial compounds such as vitamins and flavonoids, and confirmed non-cytotoxic concentrations for use in experiments. However, the study was conducted in vitro, and no human subjects were involved.
    Discuss this study in the Community →

    Research cited in this study

    19 / 19 results

    Related Community Posts Join

    6 / 73 results

      community HLT Megathread on HMI-115 (key takeaways in comments)

      in Research/Science  39 upvotes 1 year ago
      HMI-115, a newly discovered hair loss treatment that could potentially be effective for those with diffuse thinning and telogen effluvium. It is based on prolactin receptor antagonist signaling and has already undergone Phase I trials in women, with potential commercialization by 2027.

      community Tropical growth stimulants other than minoxidil

      in Treatment  11 upvotes 6 months ago
      The conversation discusses alternative hair growth treatments to minoxidil, including Stemoxydine, Tretinoin, adenosine, Baicalin, castor oil, Latanoprost/bimatoprost, and Redensyl. Users share their experiences and opinions on the efficacy of these treatments.

      community Bryan Johnson just dropped his anti hair loss formula

      in Treatment  339 upvotes 10 months ago
      Bryan Johnson shared his hair loss treatment, which mainly relies on minoxidil and finasteride. Some users are skeptical of his results, while others appreciate his efforts in anti-aging and hair loss research.

      community Helicobacter's concocted serum v1

       7 upvotes 5 years ago
      A custom-made serum based on double-blind studies for AGA, which includes natural ingredients such as rosemary oil, procyanidin B-2, saw palmetto extract, curcuma aeruginosa, pumpkin seed oil and castor oil. The user has updated their recipe to include apple poly procyanidin B-2 4% concentration and other ingredients before topping it off with Pura d'or serum.

      community Natural Remedies: Polyphenols and Hair Loss

       19 upvotes 5 years ago
      Natural remedies to treat hair loss, such as polyphenols, apple peel extract, grape seed extract, green tea extract, peppermint oil, pumpkin seed oil, apigenin, Ginkgo biloba, red clover extract, olive leaf extract, Ecklonia Cava and Grateloupia elliptica. In addition, terpenes, carotenoids, and tocopherols were discussed as potential treatments.

      community Pyrilutamide - your experience?

      in Product  12 upvotes 1 year ago
      The conversation is about the lack of improvement in hair loss after using Pyrilutamide for 14 weeks, with the original poster unable to use Finasteride due to depression. Replies suggest that Pyrilutamide, like RU58841, may not work for everyone, and a more potent drug is being developed by Kintor.

    Similar Research

    5 / 1000+ results