Allergic Contact Dermatitis from Dyes in Wigs Following Diphenylcyclopropenone Treatment

A 36-year-old woman with alopecia universalis developed severe allergic contact dermatitis from dyes in wigs following diphencyprone (DPCP) treatment. She experienced severe scalp and generalized eczema without hair regrowth, leading to discontinuation of DPCP. Patch testing revealed a strong reaction to para-phenylenediamine (PPD) in the wig dyes. Despite attempts to use barrier methods and switch to human-hair wigs without dyes, she continued to experience scalp dermatitis. Significant improvement was achieved by avoiding dyed wigs and clothing. This case highlighted the potential for severe allergic reactions to dyes following DPCP treatment, emphasizing the need for careful management of contact allergens in patients undergoing such treatments.