Drug Armamentarium for Alopecia Areata

    February 2021 in “ Journal of pharmaceutical and biological sciences ”
    Sunil Chaudhry
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    TLDR No cure exists for alopecia areata, and treatments are personalized.
    Alopecia areata (AA) is an autoimmune condition causing nonscarring hair loss on the scalp and/or body, affecting 1-2% of people of all ages and leading to significant emotional and psychological stress. Despite various therapeutic options, including corticosteroids, JAK inhibitors, and minoxidil, none are curative or preventive, and treatment plans are tailored to the patient's age and disease extent. The global market for alopecia treatments was valued at $2.54 billion in 2018 and was expected to reach $3.98 billion by 2025, growing at a CAGR of 5.80%.
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      Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

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