Alopecia Areata: A New Treatment Plan

July 2011 in “ Clinical, cosmetic and investigational dermatology ”

Adel Alsantali

TLDR The document suggests a personalized treatment plan for alopecia areata based on the patient's age and hair loss severity, using a range of therapies ranked by effectiveness and safety.

The document reviewed various treatments for alopecia areata, including intralesional corticosteroids, topical minoxidil, anthralin, topical sensitizers, and systemic treatments like corticosteroids and cyclosporine, noting their efficacy and side effects. It highlighted the ineffectiveness of TNF blockers and certain topical treatments for eyelash growth, while therapies like hypnotherapy, aromatherapy, garlic gel, and zinc supplementation showed some promise. Simvastatin and ezetimibe therapy led to hair growth in some cases. The review emphasized the need for individualized treatment plans due to variable responses and potential adverse effects.

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research Efficacy and Tolerability of Methotrexate in Severe Childhood Alopecia Areata

70 citations , July 2011 in “British journal of dermatology/British journal of dermatology, Supplement”

Methotrexate sometimes helps regrow hair in children with severe alopecia areata and is generally safe.

research Treatment Effects of Intradermal Botulinum Toxin Type A Injection on Alopecia Areata

24 citations , December 2010 in “Dermatologic surgery”

Botulinum toxin type A injections are not effective for severe alopecia areata.

research Photodynamic Therapy with Methyl 5-Aminolevulinate Acid Might Be Ineffective in Recalcitrant Alopecia Totalis Regardless of Using a Microneedle Roller to Increase Skin Penetration

27 citations , May 2010 in “Dermatologic surgery”

Photodynamic therapy with methyl 5-aminolevulinic acid is ineffective for treating alopecia totalis.

research Latanoprost in the Treatment of Eyelash Alopecia in Alopecia Areata Universalis

50 citations , April 2010 in “Journal of The European Academy of Dermatology and Venereology”

Latanoprost can effectively treat eyelash hair loss, with 45% of patients showing hair regrowth and no reported side effects.

research Alopecia Areata Update

244 citations , February 2010 in “Journal of the American Academy of Dermatology”

The document says current treatments for alopecia areata do not cure or prevent it, and it's hard to judge their effectiveness due to spontaneous remission and lack of studies.

research Bimatoprost in the Treatment of Eyelash Universalis Alopecia Areata

37 citations , January 2010 in “International Journal of Trichology”

Bimatoprost helped eyelash growth in nearly half of the patients with a type of eyelash hair loss.

research Phase I/II Randomized Bilateral Half-Head Comparison of Topical Bexarotene 1% Gel for Alopecia Areata

44 citations , October 2009 in “Journal of the American Academy of Dermatology”

Topical bexarotene 1% gel might help regrow hair in alopecia areata and is generally safe.

research 308-nm Excimer Laser for the Treatment of Alopecia Areata in Children

79 citations , September 2009 in “Pediatric dermatology”

The 308-nm Excimer laser is effective and safe for treating patchy alopecia areata in children.

research Lack of Efficacy of Topical Latanoprost and Bimatoprost Ophthalmic Solutions in Promoting Eyelash Growth in Patients with Alopecia Areata

55 citations , April 2009 in “Journal of The American Academy of Dermatology”

Topical latanoprost and bimatoprost eye solutions don't help eyelash growth in people with alopecia areata.

research The Therapeutic Effect and Changed Serum Zinc Level After Zinc Supplementation in Alopecia Areata Patients with Low Serum Zinc Level

65 citations , January 2009 in “Annals of Dermatology”

Zinc supplements increased zinc levels in some hair loss patients but didn't significantly improve hair growth.

research Alopecia Areata Following Adalimumab

38 citations , January 2009 in “Journal of Cutaneous Medicine and Surgery”

A woman developed hair loss after starting a treatment with adalimumab, suggesting this medication might cause hair loss.

research Treatment of Persistent Alopecia Areata with Sulfasalazine

45 citations , July 2008 in “International Journal of Dermatology”

Sulfasalazine may help treat persistent alopecia areata.

research Lack of Response of Alopecia Areata to Pimecrolimus Cream

26 citations , July 2007 in “Clinical and experimental dermatology”

Pimecrolimus cream is not effective for treating alopecia areata.

research Changes in Distribution Pattern of CD8 Lymphocytes in the Scalp in Alopecia Areata During Treatment With Diphenylcyclopropenone

27 citations , May 2007 in “Archives of dermatological research”

Diphencyprone treatment increases CD8 lymphocytes in the scalp, which is associated with hair regrowth in alopecia areata patients.

research Development of Alopecia Areata Universalis in a Patient Receiving Adalimumab

69 citations , December 2006 in “Archives of dermatology”

Adalimumab may cause severe hair loss in some patients.

research Lack of Efficacy of Topical Latanoprost in the Treatment of Eyebrow Alopecia Areata

36 citations , December 2005 in “Journal of The American Academy of Dermatology”

Topical latanoprost doesn't effectively regrow hair in severe eyebrow alopecia areata cases.

research Alopecia Areata Presenting in Two Kidney-Pancreas Transplant Recipients Taking Cyclosporine

23 citations , November 2005 in “Journal of The American Academy of Dermatology”

Two transplant patients on cyclosporine unexpectedly developed hair loss.

research Topical Immunotherapy of Severe Alopecia Areata with Diphenylcyclopropenone: Experience in an Iranian Population

36 citations , May 2005 in “BMC dermatology”

DPCP is effective for treating severe alopecia areata, but relapse is common.

research Management of Hair Loss

74 citations , April 2005 in “Dermatologic Clinics”

Minoxidil and finasteride are effective for male hair loss, minoxidil for female hair loss, and various treatments like corticosteroids work for alopecia areata; treatment should be tailored to the individual.

research Comparison of Azelaic Acid and Anthralin for the Therapy of Patchy Alopecia Areata

27 citations , January 2005 in “American Journal of Clinical Dermatology”

Azelaic acid and anthralin are similarly effective for treating patchy hair loss.

research Hypertrichosis of the Eyelashes Caused by Bimatoprost

65 citations , November 2004 in “Journal of the American Academy of Dermatology”

Bimatoprost can cause excessive eyelash growth.

research Hypertrichosis of Vellus Hairs in the Malar Region After Unilateral Treatment with Bimatoprost

15 citations , April 2004 in “American Journal of Ophthalmology”

Using bimatoprost on one side of the face caused increased cheek hair growth in a patient.

research Clobetasol Propionate 0.05% Under Occlusion in the Treatment of Alopecia Totalis/Universalis

146 citations , July 2003 in “Journal of the American Academy of Dermatology”

Clobetasol propionate ointment can help some people with total hair loss regrow hair.

research Efficacy of Betamethasone Valerate Foam Formulation in Comparison with Betamethasone Dipropionate Lotion in the Treatment of Mild-to-Moderate Alopecia Areata: A Multicenter, Prospective, Randomized, Controlled, Investigator-Blinded Trial

66 citations , July 2003 in “International Journal of Dermatology”

Betamethasone valerate foam is more effective and safe for treating mild-to-moderate alopecia areata than betamethasone dipropionate lotion.

research Topical Tacrolimus (FK506): Treatment Failure in Four Cases of Alopecia Universalis

19 citations , September 2002 in “Acta dermato-venereologica”

Topical tacrolimus did not regrow hair in alopecia universalis patients.

research Sulfasalazine for Alopecia Areata

62 citations , April 2002 in “Journal of the American Academy of Dermatology”

Sulfasalazine may help regrow hair in severe alopecia areata cases.

research Multi-Injection Plate for Intralesional Corticosteroid Treatment of Patchy Alopecia Areata

16 citations , July 2000 in “Dermatologic surgery”

The multi-injection plate is a less painful and more efficient method for treating patchy hair loss.

research Randomized Trial of Aromatherapy

122 citations , November 1998 in “Archives of Dermatology”

Aromatherapy with certain essential oils is a safe and effective treatment for hair growth in alopecia areata patients.

research Alopecia areata in a renal transplant recipient on cyclosporin

12 citations , November 1996 in “Australasian journal of dermatology”

A kidney transplant patient on cyclosporin experienced unexpected severe hair loss, which improved with treatment adjustments.

research PUVA treatment of alopecia areata partialis, totalis and universalis: audit of 10 years' experience at St John's Institute of Dermatology

105 citations , December 1995 in “British journal of dermatology/British journal of dermatology, Supplement”

PUVA treatment is generally ineffective for alopecia areata.

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research Twenty Nail Dystrophy with Alopecia Areata in an Atopic Child

April 2019 in “International journal of research in dermatology”

A child with rough nails also had hair loss and allergies.