Alopecia Areata: A New Treatment Plan

July 2011 in “ Clinical, cosmetic and investigational dermatology ”

Adel Alsantali

alopecia areata intralesional corticosteroids topical minoxidil anthralin topical sensitizers systemic corticosteroids cyclosporine TNF blockers hypnotherapy aromatherapy garlic gel zinc supplementation simvastatin ezetimibe Rogaine

From the encyclopedia

Alopecia Areata →

autoimmune disorder causing patchy hair loss

Minoxidil →

An essential vasodilator with some anti-androgenic effects

Studysummary This review discusses various therapeutic agents for alopecia areata, categorized by efficacy and safety, and highlights the lack of curative treatments and long-term outcome studies.

Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer

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Research cited in this study

44 / 44 results

research Efficacy and Tolerability of Methotrexate in Severe Childhood Alopecia Areata

70 citations , April 2011 in “British journal of dermatology/British journal of dermatology, Supplement”

This retrospective study found that methotrexate had variable efficacy in treating severe alopecia areata in children, with successful hair regrowth observed in five out of thirteen assessable cases.

research Treatment Effects of Intradermal Botulinum Toxin Type A Injection on Alopecia Areata

24 citations , December 2010 in “Dermatologic surgery”

In this study, BTXA injections did not effectively treat recalcitrant alopecia areata or improve hair regrowth in most patients, suggesting its limitations as an alternative therapy.

Photodynamic Therapy with Methyl 5-Aminolevulinate Acid Might Be Ineffective in Recalcitrant Alopecia Totalis Regardless of Using a Microneedle Roller to Increase Skin Penetration

research Photodynamic Therapy with Methyl 5-Aminolevulinate Acid Might Be Ineffective in Recalcitrant Alopecia Totalis Regardless of Using a Microneedle Roller to Increase Skin Penetration

27 citations , May 2010 in “Dermatologic surgery”

This study found that photodynamic therapy with methyl 5-aminolevulinic acid was ineffective for treating alopecia totalis, even with microneedle rolling to enhance drug delivery.

research Alopecia Areata Update

244 citations , January 2010 in “Journal of the American Academy of Dermatology”

This review discusses treatment options for alopecia areata and suggests tailored treatment plans, noting the challenges posed by spontaneous remission and limited high-quality clinical trials.

research Bimatoprost in the Treatment of Eyelash Universalis Alopecia Areata

37 citations , January 2010 in “International Journal of Trichology”

In this 1-year study of patients with alopecia areata universalis, researchers found that 0.03% topical bimatoprost led to an acceptable cosmetic response in 43.24% of participants.

research Latanoprost in the Treatment of Eyelash Alopecia in Alopecia Areata Universalis

50 citations , December 2009 in “Journal of The European Academy of Dermatology and Venereology”

This study found that latanoprost may be effective for treating eyelash alopecia areata, achieving cosmetically acceptable regrowth in 45% of patients.

research Phase I/II Randomized Bilateral Half-Head Comparison of Topical Bexarotene 1% Gel for Alopecia Areata

44 citations , October 2009 in “Journal of the American Academy of Dermatology”

This study reported that 1% bexarotene gel was well tolerated and possibly effective for inducing partial hair regrowth in alopecia areata, but more rigorous trials are needed to confirm its efficacy.

research 308-nm Excimer Laser for the Treatment of Alopecia Areata in Children

79 citations , September 2009 in “Pediatric dermatology”

This study found that the 308-nm Excimer laser was effective and safe for treating patchy alopecia areata in children, with hair regrowth observed in 60% of treated scalp patches.

Lack of Efficacy of Topical Latanoprost and Bimatoprost Ophthalmic Solutions in Promoting Eyelash Growth in Patients with Alopecia Areata

research Lack of Efficacy of Topical Latanoprost and Bimatoprost Ophthalmic Solutions in Promoting Eyelash Growth in Patients with Alopecia Areata

55 citations , March 2009 in “Journal of The American Academy of Dermatology”

This study found that latanoprost and bimatoprost, when applied cutaneously to the eyelids, did not induce appreciable eyelash regrowth in patients with alopecia areata over 16 weeks.

The Therapeutic Effect and Changed Serum Zinc Level After Zinc Supplementation in Alopecia Areata Patients with Low Serum Zinc Level

research The Therapeutic Effect and Changed Serum Zinc Level After Zinc Supplementation in Alopecia Areata Patients with Low Serum Zinc Level

65 citations , January 2009 in “Annals of Dermatology”

In this study, oral zinc supplementation for twelve weeks increased serum zinc levels in alopecia areata patients with low zinc, showing positive hair regrowth in 66.7% of participants, though this was not statistically significant.

research Alopecia Areata Following Adalimumab

38 citations , January 2009 in “Journal of Cutaneous Medicine and Surgery”

This case report highlights a woman who developed new-onset alopecia areata after starting adalimumab for psoriatic arthritis, challenging the assumed role of TNF-alpha in the condition's pathogenesis.

research Treatment of Persistent Alopecia Areata with Sulfasalazine

45 citations , July 2008 in “International Journal of Dermatology”

This study found that oral sulfasalazine led to varying hair regrowth outcomes in patients with persistent alopecia areata, with 56.3% showing moderate to good responses.

research Changes in Distribution Pattern of CD8 Lymphocytes in the Scalp in Alopecia Areata During Treatment With Diphenylcyclopropenone

27 citations , May 2007 in “Archives of dermatological research”

In this study, alopecia areata patients treated with diphencyprone showed a significant increase in CD8 lymphocytes around hair bulbs, which may be associated with hair regrowth.

research Lack of Response of Alopecia Areata to Pimecrolimus Cream

26 citations , March 2007 in “Clinical and experimental dermatology”

Pimecrolimus cream is not effective for treating alopecia areata.

research Combination of Topical Garlic Gel and Betamethasone Valerate Cream in the Treatment of Localized Alopecia Areata: A Double-Blind Randomized Controlled Study

61 citations , January 2007 in “Indian Journal of Dermatology Venereology and Leprology”

This study found that garlic gel significantly improved the efficacy of topical betamethasone valerate in treating alopecia areata compared to placebo.

research Development of Alopecia Areata Universalis in a Patient Receiving Adalimumab

69 citations , December 2006 in “Archives of dermatology”

This entry contains no research abstract, so no scientific findings or conclusions are reported.

research Intralesional Treatment of Alopecia Areata with Triamcinolone Acetonide by Jet Injector

100 citations , July 2006 in “British Journal of Dermatology”

This study found that intralesional triamcinolone acetonide injections using a needleless injector led to rapid hair regrowth in patients with limited alopecia areata, while lasting growth was rare in alopecia totalis.

research A Comparison of the Efficacy, Relapse Rate, and Side Effects Among Three Modalities of Systemic Corticosteroid Therapy for Alopecia Areata

97 citations , January 2006 in “Dermatology”

This study found that intramuscular triamcinolone acetonide or pulse therapy effectively treats alopecia areata with manageable side effects, but further strategies are needed to reduce relapse rates.

research Lack of Efficacy of Topical Latanoprost in the Treatment of Eyebrow Alopecia Areata

36 citations , November 2005 in “Journal of The American Academy of Dermatology”

This article discusses the potential of latanoprost for treating alopecia areata, but notes that well-controlled studies are still needed to confirm its effectiveness.

research Alopecia Areata Presenting in Two Kidney-Pancreas Transplant Recipients Taking Cyclosporine

23 citations , October 2005 in “Journal of The American Academy of Dermatology”

This report describes the unexpected development of alopecia areata in kidney-pancreas transplant recipients undergoing cyclosporine-based immunosuppressive therapy, suggesting a complex relationship between the treatment and disease.

research Recurrence of Alopecia Areata in a Patient Receiving Etanercept Injections

75 citations , June 2005 in “Archives of Dermatology”

In this case report, a patient experienced a recurrence of alopecia areata while undergoing etanercept treatment, suggesting the drug may not effectively prevent this condition's return.

research Topical Immunotherapy of Severe Alopecia Areata with Diphenylcyclopropenone: Experience in an Iranian Population

36 citations , May 2005 in “BMC dermatology”

This study found that topical diphenylcyclopropenone was effective in treating severe alopecia areata but had a high relapse rate and was often accompanied by side effects like eczema and lymphadenopathy.

research Management of Hair Loss

74 citations , April 2005 in “Dermatologic Clinics”

This article reviews treatment options for male-pattern and female-pattern hair loss, telogen effluvium, and alopecia areata, but provides no new clinical results; algorithmic management approaches are included.

research Placebo-Controlled Oral Pulse Prednisolone Therapy in Alopecia Areata

141 citations , February 2005 in “Journal of the American Academy of Dermatology”

In this study, oral prednisolone pulse therapy led to significant hair regrowth in some patients with extensive alopecia areata, whereas no improvement was seen in the placebo group.

research Comparison of Azelaic Acid and Anthralin for the Therapy of Patchy Alopecia Areata

27 citations , January 2005 in “American Journal of Clinical Dermatology”

This pilot study found that azelaic acid treatment for patchy alopecia areata had similar hair regrowth results as anthralin, suggesting it may be an effective topical therapy.

research Hypertrichosis of the Eyelashes Caused by Bimatoprost

65 citations , November 2004 in “Journal of the American Academy of Dermatology”

This article reports a case where the IOP-lowering drug bimatoprost was associated with eyelash hypertrichosis.

research Hypertrichosis of Vellus Hairs in the Malar Region After Unilateral Treatment with Bimatoprost

15 citations , March 2004 in “American Journal of Ophthalmology”

This case report found that topical bimatoprost in a female Hispanic patient with glaucoma led to increased hair growth and pigmentation in the malar region, which resolved after discontinuing use and epilation.

Efficacy of Betamethasone Valerate Foam Formulation in Comparison with Betamethasone Dipropionate Lotion in the Treatment of Mild-to-Moderate Alopecia Areata: A Multicenter, Prospective, Randomized, Controlled, Investigator-Blinded Trial

research Efficacy of Betamethasone Valerate Foam Formulation in Comparison with Betamethasone Dipropionate Lotion in the Treatment of Mild-to-Moderate Alopecia Areata: A Multicenter, Prospective, Randomized, Controlled, Investigator-Blinded Trial

66 citations , July 2003 in “International Journal of Dermatology”

This study found that betamethasone valerate foam was more effective and well-tolerated than betamethasone dipropionate lotion in treating mild-to-moderate alopecia areata, with higher hair regrowth rates observed.

research Clobetasol Propionate 0.05% Under Occlusion in the Treatment of Alopecia Totalis/Universalis

146 citations , July 2003 in “Journal of the American Academy of Dermatology”

In this study, clobetasol propionate 0.05% ointment was found to induce hair regrowth in 28.5% of patients with severe alopecia areata under occlusive conditions, though long-term benefit was limited to 17.8%.

research Topical Tacrolimus (FK506): Treatment Failure in Four Cases of Alopecia Universalis

19 citations , September 2002 in “Acta dermato-venereologica”

In this retrospective study, anti-tuberculous agents, likely rifampicin, were effective adjunctive therapies for a chalazion, coinciding with spontaneous drainage in a patient with rosacea.

research Onion Juice (Allium Cepa L.), A New Topical Treatment For Alopecia Areata

95 citations , June 2002 in “The Journal of Dermatology”

In this study, using topical crude onion juice significantly improved hair regrowth in patients with patchy alopecia areata compared to tap water.

research Sulfasalazine for Alopecia Areata

62 citations , April 2002 in “Journal of the American Academy of Dermatology”

In this study, sulfasalazine treatment resulted in cosmetically acceptable hair regrowth in 23% of patients with severe alopecia areata in whom a response could be determined.

research Multi-Injection Plate for Intralesional Corticosteroid Treatment of Patchy Alopecia Areata

16 citations , July 2000 in “Dermatologic surgery”

This paper contains author contact information and disclosures without reporting new research findings or results.

research Twice Weekly 5 mg Dexamethasone Oral Pulse in the Treatment of Extensive Alopecia Areata

65 citations , September 1999 in “The Journal of Dermatology”

In this study, complete to excellent hair regrowth was observed in 63.3% of patients with extensive alopecia areata treated with biweekly dexamethasone pulses, although mild side effects were frequent.

research Randomized Trial of Aromatherapy for Alopecia Areata

122 citations , November 1998 in “Archives of Dermatology”

This study found that aromatherapy involving essential oils significantly improved symptoms of alopecia areata compared to carrier oils alone in a randomized controlled trial.

research Alopecia Areata in a Renal Transplant Recipient on Cyclosporin

12 citations , November 1996 in “Australasian journal of dermatology”

A kidney transplant patient on cyclosporin experienced unexpected severe hair loss, which improved with treatment adjustments.

research PUVA Treatment of Alopecia Areata Partialis, Totalis, and Universalis: Audit of 10 Years' Experience at St John's Institute of Dermatology

105 citations , December 1995 in “British journal of dermatology/British journal of dermatology, Supplement”

This retrospective study concluded that PUVA treatment is generally ineffective for alopecia areata, with low effective success rates for partialis, totalis, and universalis types.

research Treatment-Resistant Alopecia Areata: Response to Combination Therapy with Minoxidil Plus Anthralin

36 citations , June 1990 in “Archives of Dermatology”

This study found that combination therapy with 5% minoxidil and 0.5% anthralin led to hair regrowth in some patients with severe treatment-resistant alopecia areata, but also caused mild to moderate irritant dermatitis in all participants.

research Selective Changes in Lymphocytic Differentiation Antigens in the Peripheral Blood of Patients with Alopecia Areata Treated with Oral Zinc

11 citations , February 1990 in “PubMed”

This study found that zinc treatment in alopecia areata patients may increase CD8+ cells, suggesting its effectiveness could be due to immunomodulation.