Alopecia Areata Presenting in Two Kidney-Pancreas Transplant Recipients Taking Cyclosporine

The document described two cases of alopecia areata (AA), a condition causing hair loss, in kidney-pancreas transplant recipients who were taking cyclosporine, an immunosuppressive drug. This finding was unexpected because cyclosporine is known to help treat AA due to its immunomodulatory effects. These two cases contribute to a small number of similar reports, totaling nine cases of AA in solid organ transplant recipients on cyclosporine. Both patients developed AA years after their transplant despite being on a stable dose of cyclosporine for over a year. Treatment with intralesional corticosteroids led to hair regrowth, but new AA patches appeared as the treated ones resolved. The paper highlights the complexity of AA's immunologic basis and the need for more research into the immune dysregulation associated with the disease.