TLDR Two transplant patients on cyclosporine unexpectedly developed hair loss.
The document described two cases of alopecia areata (AA), a condition causing hair loss, in kidney-pancreas transplant recipients who were taking cyclosporine, an immunosuppressive drug. This finding was unexpected because cyclosporine is known to help treat AA due to its immunomodulatory effects. These two cases contribute to a small number of similar reports, totaling nine cases of AA in solid organ transplant recipients on cyclosporine. Both patients developed AA years after their transplant despite being on a stable dose of cyclosporine for over a year. Treatment with intralesional corticosteroids led to hair regrowth, but new AA patches appeared as the treated ones resolved. The paper highlights the complexity of AA's immunologic basis and the need for more research into the immune dysregulation associated with the disease.
12 citations,
November 2003 in “Journal of the American Academy of Dermatology” Topical diphencyprone helped regrow hair in mice and rats with a condition similar to human hair loss.
30 citations,
January 1999 in “Dermatology” Cyclosporine A can help some people with severe alopecia areata regrow hair.
12 citations,
November 1996 in “Australasian journal of dermatology” A kidney transplant patient on cyclosporin experienced unexpected severe hair loss, which improved with treatment adjustments.
1 citations,
May 2017 in “InTech eBooks” New treatments focusing on immune pathways show promise for stubborn hair loss.
January 2024 in “Journal der Deutschen Dermatologischen Gesellschaft” Non-biologic immunosuppressive drugs are crucial for treating autoimmune and chronic inflammatory skin diseases.
29 citations,
June 2013 in “Journal of the Saudi Society of Dermatology & Dermatologic Surgery” Alopecia areata is an autoimmune hair loss condition treated with corticosteroids, and histologic confirmation is the best diagnosis method.
24 citations,
January 2008 in “KARGER eBooks” The document concludes that ongoing research using animal models is crucial for better understanding and treating Alopecia Areata.
70 citations,
October 2020 in “The journal of allergy and clinical immunology/Journal of allergy and clinical immunology/The journal of allergy and clinical immunology” Janus kinase inhibitors are promising drugs for treating autoimmune and inflammatory diseases.
