Alopecia Universalis Treated With Oral Cyclosporine A And Prednisolone: Immunologic Studies

    July 1992 in “ International Journal of Dermatology ”
    Hideki Teshima, Atsumichi Urabe, Masahiro Irie, Tetsuya Nakagawa, Juichiro NAKAYAMA, Yoshiaki Hori
    TLDR Oral cyclosporine A and prednisolone effectively improved alopecia universalis without side effects.
    The study investigated the treatment of alopecia universalis, a challenging condition, using immunotherapy in 6 patients. The treatment involved oral administration of cyclosporine A (2.5 mg/kg) and prednisolone (5 mg/day), which led to significant symptomatic improvement without side effects due to the low dosage. More than 6 months post-treatment, no recurrence of alopecia was observed. Immunologic studies showed enhanced function, with increases in cos-positive T cells, NK cells, and C3, and reductions in active CD4 cells, eosinophils, and circulating immune complexes. Histological analysis revealed T-cell infiltration around hair matrices, which resolved after treatment. These findings suggested that immunologic abnormalities were linked to alopecia universalis, and the treatment was effective in addressing these issues.
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