TLDR Topical tacrolimus did not regrow hair in alopecia universalis patients.
In a study involving 4 patients (2 females and 2 males, aged 17 to 27) with alopecia universalis, topical tacrolimus (0.1% solution or ointment) was applied twice daily for 12 weeks. Despite previous reports of success in animal models, no hair regrowth was observed in any of the patients during the treatment period or the 6-month follow-up. Adverse effects such as itching, scaling, and hyperpigmentation were noted but were not severe. The study concluded that topical tacrolimus was ineffective for treating alopecia universalis, possibly due to insufficient skin penetration, inadequate treatment duration, or the severity of the disease.
85 citations,
October 2012 in “Dermatologic Clinics” Alopecia Areata is an autoimmune condition often starting before age 20, with varied treatment success and a need for personalized treatment plans.
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January 2015 in “Nasza Dermatologia Online” Some treatments for autoimmune hair loss work, but JAK inhibitors like tofacitinib are promising for regrowth.
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April 2021 in “Journal of the American Academy of Dermatology” Topical corticosteroids are the best initial treatment for children's alopecia areata.
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11 citations,
January 2022 in “Journal der Deutschen Dermatologischen Gesellschaft” Alopecia areata is a chronic condition causing hair loss, with new treatments targeting the immune system showing promise.
