Hair Thickness Growth Effect of Adenosine Complex in Male and Female Patterned Hair Loss via Inhibition of Androgen Receptor Signaling

June 2024 in “ International journal of molecular sciences ”

Jaeyoon Kim, Jae Young Shin, Yun Ho Choi, Jang Ho Joo, Mi Hee Kwack, Young Kwan Sung, Nae Gyu Kang

adenosine panthenol niacinamide androgen receptor signaling anagen stage hair follicles mitochondrial activity dermal papilla cells minoxidil androgenetic alopecia MNX Rogaine

From the encyclopedia

Adenosine →

nucleoside used for hair regrowth stimulant properties

Panthenol →

Niacinamide →

Studysummary In this study, researchers found that topical treatment with adenosine improved hair growth and thickness by significantly increasing hair density and thickness after four months in vivo, with results comparable to minoxidil, potentially due to adenosine's anti-androgenic effects.

Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer

The study examined the effects of an adenosine complex (0.75% adenosine, 1% panthenol, and 2% niacinamide; APN) on hair growth in individuals with male- and female-patterned hair loss. Adenosine was found to inhibit androgen receptor signaling, elongate the anagen stage of hair follicles, and increase mitochondrial activity in dermal papilla cells. In a 4-month study involving 271 Korean participants, both APN and 5% minoxidil (MNX) significantly increased hair density and thickness, with APN showing a +10.32% increase in hair thickness. The results suggest that adenosine's anti-androgenic effects and its impact on hair thickness distribution could offer new treatment approaches for androgenetic alopecia.

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