Deciphering the Molecular Morphology of the Human Hair Cycle: Wnt Signalling During the Telogen–Anagen Transformation

September 2019 in “ British Journal of Dermatology ”

Nathan J Hawkshaw, Jonathan A. Hardman, Majid Alam, Francisco Jiménez, Ralf Paus

hair cycle Wnt signalling telogen anagen telogen-anagen transformation

TLDR Wnt signaling is important for the change from the resting phase to the growth phase in human hair cycles.

We don't know much about this study yet.

We're maintaining the world's largest resposity of hair loss research. You can help out the community by sending a PDF of this study here . Not sure how to get a study's PDF? You can email the authors of the study.

View this study on academic.oup.com →

Discuss this study in the Community →

Cited in this study

27 / 27 results

research A Technique for More Precise Distinction Between Catagen and Telogen Human Hair Follicles Ex Vivo

9 citations , September 2018 in “Journal of The American Academy of Dermatology”

Researchers developed a new method using methylene blue staining to more accurately identify the growth stage of human hair follicles.

research Identifying Novel Strategies for Treating Human Hair Loss Disorders: Cyclosporine A Suppresses the Wnt Inhibitor, SFRP1, in the Dermal Papilla of Human Scalp Hair Follicles

68 citations , May 2018 in “PLOS Biology”

Cyclosporine A may help treat hair loss by blocking a protein that inhibits hair growth.

research WNT10A Mutation Causes Ectodermal Dysplasia by Impairing Progenitor Cell Proliferation and KLF4-Mediated Differentiation

96 citations , June 2017 in “Nature Communications”

A WNT10A gene mutation leads to ectodermal dysplasia by disrupting cell growth and differentiation.

research Hair Follicle Stem Cell Proliferation, Akt and Wnt Signaling Activation in TPA-Induced Hair Regeneration

30 citations , February 2017 in “Histochemistry and Cell Biology”

TPA promotes hair growth by increasing stem cell activity and activating specific cell signals.

research A Guide to Studying Human Hair Follicle Cycling In Vivo

212 citations , January 2016 in “Journal of Investigative Dermatology”

The document provides a method to classify human hair growth stages using a model with human scalp on mice, aiming to standardize hair research.

research Human Hair Follicle Organ Culture: Theory, Application, and Perspectives

130 citations , November 2015 in “Experimental Dermatology”

Human hair follicle organ culture is a useful model for hair research with potential for studying hair biology and testing treatments.

research Re-Evaluating Cyclosporine A as a Hair Growth–Promoting Agent in Human Scalp Hair Follicles

29 citations , August 2015 in “Journal of Investigative Dermatology”

Cyclosporine A promotes hair growth and prolongs the active growth phase in human hair follicles, but may work differently than in rodents.

research The Okuda Papers: An Extraordinary But Unfortunately Unrecognized Piece of Work That Could Have Changed the History of Hair Transplantation

8 citations , February 2015 in “Experimental Dermatology”

Dr. Shoji Okuda's pioneering work on hair transplantation was overlooked and could have significantly advanced the field if recognized sooner.

research Resting No More: Redefining Telogen, the Maintenance Stage of the Hair Growth Cycle

120 citations , November 2014 in “Biological Reviews”

The telogen phase of hair growth is active and important for preparing hair follicles for regeneration, not just a resting stage.

research Neuroendocrinology of the Hair Follicle: Principles and Clinical Perspectives

98 citations , October 2014 in “Trends in Molecular Medicine”

Hair follicles are hormone-sensitive and involved in growth and other functions, with potential for new treatments, but more research is needed.

research Human Epithelial Hair Follicle Stem Cells and Their Progeny: Current State of Knowledge, the Widening Gap in Translational Research and Future Challenges

106 citations , March 2014 in “BioEssays”

We need more research to better understand human hair follicle stem cells for improved treatments for hair loss and skin cancer.

research An Overview of Alopecias

53 citations , March 2014 in “Cold Spring Harbor Perspectives in Medicine”

The document explains different types of hair loss, their causes, and treatments, and suggests future research areas.

research In Vivo Transcriptional Governance of Hair Follicle Stem Cells by Canonical Wnt Regulators

173 citations , January 2014 in “Nature Cell Biology”

Wnt signaling controls whether hair follicle stem cells stay inactive or regenerate hair.

research Stem Cell Dynamics in the Hair Follicle Niche

135 citations , January 2014 in “Seminars in Cell & Developmental Biology”

Stem cells in the hair follicle are regulated by their surrounding environment, which is important for hair growth.

research Androgenetic Alopecia: Identification Of Four Genetic Risk Loci And Evidence For The Contribution Of WNT Signaling To Its Etiology

74 citations , June 2013 in “Journal of Investigative Dermatology”

Four genetic risk spots found for hair loss, with WNT signaling involved and a link to curly hair.

research How to Diagnose and Treat Women with Excessive Hair

17 citations , January 2013 in “Dermatologic clinics”

Treating excessive hair in women requires a holistic approach, including medical, aesthetic, and emotional support.

research Hair Restoration Surgery: The State of the Art

32 citations , January 2013 in “Aesthetic Surgery Journal”

Hair restoration surgery has advanced, focusing on natural results and may improve further with new techniques and therapies.

research Epithelial Wnt Ligand Secretion Is Required for Adult Hair Follicle Growth and Regeneration

170 citations , January 2013 in “Journal of Investigative Dermatology”

Wnt ligands are crucial for hair growth and repair.

research Mesenchymal–Epithelial Interactions During Hair Follicle Morphogenesis and Cycling

300 citations , October 2012 in “Seminars in Cell & Developmental Biology”

The conclusion is that certain cell interactions and signals are crucial for hair growth and regeneration.

research Live Imaging of Stem Cell and Progeny Behavior in Physiological Hair-Follicle Regeneration

305 citations , July 2012 in “Nature”

Hair regeneration needs dynamic cell behavior and mesenchyme presence for stem cell activation.

research Utilizing the Hair Follicle to Dissect the Regulation and Autocrine/Paracrine Activities of Prolactin in Humans

12 citations , May 2012 in “Endocrinology and metabolism/American journal of physiology: endocrinology and metabolism”

Human scalp hair follicles can be used to study how prolactin affects hair growth and cell death.

research Valproic Acid Induces Hair Regeneration in Murine Model and Activates Alkaline Phosphatase Activity in Human Dermal Papilla Cells

85 citations , April 2012 in “PLOS ONE”

Valproic Acid helps regrow hair in mice and activates a hair growth marker in human cells.

research Beta-Catenin Activity in the Dermal Papilla Regulates Morphogenesis and Regeneration of Hair

314 citations , April 2010 in “Developmental Cell”

β-catenin in the dermal papilla is crucial for normal hair growth and repair.

research Mind the Gender Gap: Does Prolactin Exert Gender and Site-Specific Effects on the Human Hair Follicle?

36 citations , March 2010 in “Journal of Investigative Dermatology”

Prolactin may affect hair growth differently based on gender and scalp area.

research The Hair Follicle as a Dynamic Mini-Organ

759 citations , February 2009 in “Current Biology”

Hair follicles are complex, dynamic mini-organs that help us understand cell growth, death, migration, and differentiation, as well as tissue regeneration and tumor biology.

research The Hair Follicle as an Estrogen Target and Source

159 citations , July 2006 in “Endocrine Reviews”

Estrogens significantly influence hair growth by interacting with receptors in hair follicles and may help regulate the hair growth cycle.

research The Biology of Hair Follicles

1113 citations , August 1999 in “The New England Journal of Medicine”

Hair follicle biology advancements may lead to better hair growth disorder treatments.

2 / 2 results

research Morphogenesis, Growth Cycle, and Molecular Regulation of Hair Follicles

21 citations , May 2022 in “Frontiers in Cell and Developmental Biology”

Hair growth and health are influenced by factors like age, environment, and nutrition, and are controlled by various molecular pathways. Red light can promote hair growth, and understanding these processes can help treat hair-related diseases.

research Putting the Human Hair Follicle Cycle on the Map

8 citations , January 2016 in “Journal of Investigative Dermatology”

The research created a model to understand human hair growth cycle, which can help diagnose and treat hair growth disorders and test potential hair growth drugs.