Niacinamide Down-Regulates the Expression of DKK-1 and Protects Cells from Oxidative Stress in Cultured Human Dermal Papilla Cells

    October 2021 in “ Clinical, Cosmetic and Investigational Dermatology ”
    Yun Ho Choi, Jae Young Shin, Jaeyoon Kim, Nae Gyu Kang, Sang-Hwa Lee
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    TLDR Vitamin B3 may help prevent hair loss and promote hair growth by protecting scalp cells from stress and reducing hair growth-blocking proteins.
    The study found that niacinamide, or vitamin B3, can protect human dermal papilla cells (hDPCs) from oxidative stress and promote hair growth. The research showed that niacinamide decreases the expression of DKK-1, a protein that inhibits hair growth, and reduces the levels of cell senescence markers, p21 and p16. It also increases the expression of versican, a molecule involved in hair growth, and decreases the production of reactive oxygen species (ROS) induced by H2O2. This suggests that niacinamide could be used as a treatment for hair loss conditions like alopecia by preventing oxidative stress-induced cell senescence and premature entry of hair follicles into the regression phase.
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