Niacinamide Down-Regulates the Expression of DKK-1 and Protects Cells from Oxidative Stress in Cultured Human Dermal Papilla Cells

October 2021 in “ Clinical, Cosmetic and Investigational Dermatology ”

Yun Ho Choi, Jae Young Shin, Jaeyoon Kim, Nae Gyu Kang, Sang-Hwa Lee

niacinamide vitamin B3 human dermal papilla cells oxidative stress DKK-1 cell senescence markers p21 p16 versican reactive oxygen species H2O2 alopecia hair follicles regression phase hDPCs ROS hydrogen peroxide

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Niacinamide →

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Studysummary In this study on cultured human dermal papilla cells, researchers found that niacinamide may enhance hair growth by reducing oxidative stress-induced cell senescence and delaying catagen entry, suggesting potential applications against hair loss.

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Research cited in this study

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research Topical Niacinamide Does Not Stimulate Hair Growth Based on the Existing Body of Evidence

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research Hair Growth Promoting Effect of Houttuynia Cordata Extract in Cultured Human Hair Follicle Dermal Papilla Cells

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This study suggests that Houttuynia cordata extract may promote hair growth by stimulating dermal papilla cell proliferation and extending the anagen phase through enhanced energy metabolism and gene expression changes.

research Dickkopf-1 Expression in Androgenetic Alopecia and Alopecia Areata in Male Patients

9 citations , January 2019 in “American Journal of Dermatopathology”

This study found that both androgenetic alopecia and alopecia areata showed significantly increased DKK-1 expression, potentially implicating it in the pathogenesis and as a treatment target for these conditions.

research Review of Hair Follicle Dermal Papilla Cells as In Vitro Screening Model for Hair Growth

76 citations , August 2018 in “International Journal of Cosmetic Science”

This review discusses the use of Dermal Papilla cells as in vitro models for studying hair growth modulators, emphasizing their role in aiding the development of new hair treatments, but reports no new clinical results.

research Topically Applied Nicotinamide Inhibits Human Hair Follicle Growth Ex Vivo

13 citations , December 2017 in “The journal of investigative dermatology/Journal of investigative dermatology”

This study observed that nicotinamide can effectively inhibit human hair growth and promote hair follicle regression in cultured human scalp models without negatively affecting epidermal vitality, suggesting its potential as a hair growth inhibitor in cosmetic applications.

research Diet and Hair Loss: Effects of Nutrient Deficiency and Supplement Use

79 citations , January 2017 in “Dermatology practical & conceptual”

This article addresses the need to screen for nutrient deficiencies in patients with hair loss but reports no new findings, noting that supplementation without deficiency may not be beneficial and could pose risks.

research Stress-Induced Premature Senescence of Dermal Papilla Cells Compromises Hair Follicle Epithelial-Mesenchymal Interaction

35 citations , January 2017 in “Journal of Dermatological Science”

This study suggests that stress-induced premature senescence of dermal papilla cells may contribute to hair follicle aging by impairing critical epithelial-mesenchymal interactions and promoting inflammatory cytokine production.

research Stress And The Hair Growth Cycle: Cortisol-Induced Hair Growth Disruption

69 citations , August 2016 in “PubMed”

This article discusses the relationship between cortisol, stress, and hair follicle function and highlights oral supplementation with a specific proteoglycan as a promising treatment for stress-related hair growth disorders, but it does not present new clinical results.

research Topical Adenosine Increases Thick Hair Ratio in Japanese Men with Androgenetic Alopecia

11 citations , April 2015 in “International Journal of Cosmetic Science”

This study found that topical adenosine significantly increased the ratio of thick hairs and contributed to global improvement in Japanese men with androgenetic alopecia compared to niacinamide, with no observed adverse events.

research Oxidative Stress-Associated Senescence in Dermal Papilla Cells of Men with Androgenetic Alopecia

93 citations , February 2015 in “Journal of Investigative Dermatology”

This study suggests that oxidative stress may contribute to androgenetic alopecia by inducing premature senescence and secretion of hair growth inhibitors in dermal papilla cells from balding scalp.

research Modulating Hair Follicle Size with Wnt10b/DKK1 During Hair Regeneration

53 citations , April 2014 in “Experimental Dermatology”

In this study, ectopic Wnt10b-mediated β-catenin activation in hair follicles resulted in larger regenerating anagen hair structures, an effect modulated by the Wnt inhibitor DKK1.

research Hypothalamic–Pituitary–Thyroid Axis Hormones Stimulate Mitochondrial Function and Biogenesis in Human Hair Follicles

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research Sprouty/FGF Signaling Regulates Proximal–Distal Feather Morphology and Dermal Papillae Size

50 citations , September 2012 in “Developmental Biology”

This study found that over-expressing Spry4 and Fgf10 modulates feather stem cells to alter feather morphologies in distinct ways, affecting barb branch formation and tissue structure.

research Review of Hair Follicle Dermal Cells

321 citations , December 2009 in “Journal of Dermatological Science”

This review discusses the role of dermal cells in hair follicle regeneration and morphogenesis and highlights their potential therapeutic implications, but it reports no new empirical findings.

research Premature Senescence of Balding Dermal Papilla Cells In Vitro Is Associated With p16INK4a Expression

141 citations , November 2007 in “Journal of Investigative Dermatology”

This study found that balding dermal papilla cells show premature senescence and altered expression of stress and DNA damage markers, suggesting sensitivity to environmental stress in androgenetic alopecia.

research Dihydrotestosterone-Inducible Dickkopf 1 from Balding Dermal Papilla Cells Causes Apoptosis in Follicular Keratinocytes

171 citations , July 2007 in “Journal of Investigative Dermatology”

The researchers reported that DHT-inducible DKK-1 may play a significant role in DHT-driven balding by inhibiting hair follicle cell growth and promoting apoptosis in androgenetic alopecia.

research Follicular Miniaturization in Female Pattern Hair Loss: Clinicopathological Correlations

100 citations , June 2006 in “British Journal of Dermatology”

This study found that as hair loss severity increased in women with female pattern hair loss, the number of vellus follicles also rose, indicating miniaturization of terminal hair follicles.

research A Pilot Study Evaluating the Efficacy of Topically Applied Niacin Derivatives for Treatment of Female Pattern Alopecia

27 citations , December 2005 in “Journal of Cosmetic Dermatology”

This study found that topical application of niacin derivatives significantly increased hair fullness in women with female pattern hair loss compared to a placebo after six months.

research Niacinamide: A B Vitamin That Improves Aging Facial Skin Appearance

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This study found that topical niacinamide significantly improved the appearance of wrinkles, skin yellowing, and elasticity in aging facial skin over 12 weeks.

research Hair Cycle-Specific Expression of Versican in Human Hair Follicles

88 citations , May 2005 in “Journal of Dermatological Science”

In this study, specific versican expression was observed in the anagen phase of human hair follicles, suggesting its importance in maintaining normal hair growth.

research Nutritional Factors and Hair Loss

239 citations , July 2002 in “Clinical and Experimental Dermatology”

This review explores the role of nutritional factors in hair loss, noting that iron and l-lysine supplementation may benefit some individuals, while excessive supplements can lead to hair shedding.

research Female Pattern Hair Loss

226 citations , September 2001 in “Journal of The American Academy of Dermatology”

Hair loss in women is genetic, diagnosed by examination and biopsy, and treated with minoxidil, finasteride, or transplantation.

research Control of Hair Growth and Follicle Size by VEGF-Mediated Angiogenesis

520 citations , February 2001 in “Journal of Clinical Investigation”

This study found that VEGF significantly enhances perifollicular vascularization during the hair growth phase, accelerating hair regrowth and increasing follicle and hair size, while its inhibition retards hair growth.

Growth Factors and Cytokines in Hair Follicle Development and Cycling: Recent Insights from Animal Models and the Potentials for Clinical Therapy

research Growth Factors and Cytokines in Hair Follicle Development and Cycling: Recent Insights from Animal Models and the Potentials for Clinical Therapy

100 citations , November 1996 in “Molecular Medicine Today”

This review discusses the role of growth factors and cytokines in hair follicle development and cycling, but reports no new clinical findings on treatments for hair growth disorders.

research Growth Factors in Hair Organ Development and the Hair Growth Cycle

90 citations , October 1996 in “Dermatologic Clinics”

This study found that red ginseng oil may enhance hair growth and protect skin from UV damage in mouse models by promoting regenerative processes and reducing inflammation.

A Comparison of the Culture and Growth of Dermal Papilla Cells from Hair Follicles from Non-Balding and Balding (Androgenetic Alopecia) Scalp

research A Comparison of the Culture and Growth of Dermal Papilla Cells from Hair Follicles from Non-Balding and Balding (Androgenetic Alopecia) Scalp

19 citations , March 1996 in “British Journal of Dermatology”

This study found that dermal papilla cells from balding follicles exhibit distinct growth characteristics compared to non-balding cells, suggesting their potential as a model for understanding androgenetic alopecia.

research A Comparison of the Culture and Growth of Dermal Papilla Cells from Hair Follicles from Non-Balding and Balding (Androgenetic Alopecia) Scalp

30 citations , March 1996 in “British Journal of Dermatology”

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