A Pilot Study Evaluating the Efficacy of Topically Applied Niacin Derivatives for Treatment of Female Pattern Alopecia

    December 2005 in “ Journal of Cosmetic Dermatology
    Zoe Diana Draelos, Elaine L. Jacobson, Hyun-Tae Kim, Moonsun Kim, Myron K. Jacobson
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    TLDR Niacin derivatives may increase hair fullness in women with hair loss.
    In 2005, a pilot study investigated the effectiveness of topically applied niacin derivatives, specifically octyl nicotinate and tetradecyl nicotinate, in treating female pattern alopecia. The study was double-blinded and placebo-controlled, involving 60 female participants diagnosed with Ludwig types I-III female pattern hair loss. Of these, 40 received the active treatment and 20 were given a placebo. After a treatment period of 6 months, the results indicated a statistically significant increase in hair fullness for those using the niacin derivatives compared to the placebo group, with a P value of 0.04. The study suggested that niacin derivatives could be a beneficial long-term topical treatment for female pattern hair loss and recommended further research to confirm these findings.
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