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This study found that topical application of niacin derivatives significantly increased hair fullness in women with female pattern hair loss compared to a placebo after six months.

In this in vitro study, niacinamide was found not to stimulate VEGF synthesis across a wide range of doses.

This study found that 4-MA is a potent inhibitor of testosterone 5α-reductase in human tissues, promising potential for treating androgen-dependent skin conditions like male pattern baldness.

This review concluded that oral finasteride for men and topical minoxidil for both genders have the most evidence supporting their effectiveness and safety for treating androgenetic alopecia.

This review assessed available treatments for female pattern hair loss and found that minoxidil improved hair regrowth compared to placebo, though high-quality evidence was limited for other interventions.