120 citations
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July 2005 in “Dermatologic surgery” This study found that topical niacinamide significantly improved the appearance of wrinkles, skin yellowing, and elasticity in aging facial skin over 12 weeks.
40 citations
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January 2013 in “Clinical Cosmetic and Investigational Dermatology” In this study, niacinamide 4% and desonide 0.05% emulsions significantly improved axillary hyperpigmentation in women, with desonide demonstrating a superior depigmenting effect compared to niacinamide and placebo.
20 citations
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April 2019 in “BioMed Research International” This study found that DNA hypermethylation was present in melasma lesions, and treatments with sunscreen, niacinamide, and retinoic acid were associated with decreased methylation and clinical improvement.
2 citations
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January 2020 in “International Journal of Cosmetic Science” In this in vitro study, niacinamide was found not to stimulate VEGF synthesis across a wide range of doses.
1 citations
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April 2022 in “Toxicology and Environmental Health Sciences” This double-blind randomized placebo-controlled study found that a shampoo containing salicylic acid, panthenol, and niacinamide significantly increased hair count and improved hair loss symptoms in alopecia patients over 24 weeks, compared to a placebo, with no abnormal symptoms reported.