Anti-Hair Loss Effect of Adenosine Is Exerted by cAMP Mediated Wnt/β-Catenin Pathway Stimulation via Modulation of GSK3β Activity in Cultured Human Dermal Papilla Cells

March 2022 in “ Molecules ”

Jaeyoon Kim, Jae Il Shin, Yun Shik Choi, Nae-Gyu Kang, Sang-Hwa Lee

adenosine cAMP Wnt/β-catenin pathway GSK3β human dermal papilla cells bFGF FGF7 IGF-1 adenosine A2A receptor adenosine A2B receptor cyclic AMP Wnt pathway glycogen synthase kinase 3 beta hDPCs basic fibroblast growth factor fibroblast growth factor 7 insulin-like growth factor 1 A2A receptor A2B receptor

Studysummary This study found that adenosine promotes hair growth by stimulating the Wnt/β-catenin pathway in cultured human dermal papilla cells through activation of the adenosine receptor. Our plain-language summary of this paper — not a Tressless recommendation.

The study demonstrates that adenosine promotes hair growth in cultured human dermal papilla cells (hDPCs) by activating the Wnt/β-catenin signaling pathway through cAMP-mediated modulation of GSK3β activity. This activation enhances cell viability, mitochondrial function, and the expression of growth factors like bFGF, FGF7, and IGF-1, which are crucial for hair follicle growth. The effects are mediated through adenosine A2A and A2B receptors, suggesting that adenosine could be a potential therapeutic agent for treating hair loss.

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