Anti-Hair Loss Effect of Adenosine Is Exerted by cAMP Mediated Wnt/β-Catenin Pathway Stimulation via Modulation of GSK3β Activity in Cultured Human Dermal Papilla Cells

March 2022 in “ Molecules ”

Jaeyoon Kim, Jae Il Shin, Yun Shik Choi, Nae-Gyu Kang, Sang-Hwa Lee

adenosine cAMP Wnt/β-catenin pathway GSK3β human dermal papilla cells bFGF FGF7 IGF-1 adenosine A2A receptor adenosine A2B receptor cyclic AMP Wnt pathway glycogen synthase kinase 3 beta hDPCs basic fibroblast growth factor fibroblast growth factor 7 insulin-like growth factor 1 A2A receptor A2B receptor

TLDR Adenosine can help treat hair loss by promoting hair growth.

The study demonstrates that adenosine promotes hair growth in cultured human dermal papilla cells (hDPCs) by activating the Wnt/β-catenin signaling pathway through cAMP-mediated modulation of GSK3β activity. This activation enhances cell viability, mitochondrial function, and the expression of growth factors like bFGF, FGF7, and IGF-1, which are crucial for hair follicle growth. The effects are mediated through adenosine A2A and A2B receptors, suggesting that adenosine could be a potential therapeutic agent for treating hair loss.

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research Anti-Hair Loss Effect of Adenosine Is Exerted by cAMP Mediated Wnt/β-Catenin Pathway Stimulation via Modulation of GSK3β Activity in Cultured Human Dermal Papilla Cells

March 2022 in “Molecules”

Adenosine can help treat hair loss by promoting hair growth.