Topical Adenosine Increases the Proportion of Thick Hair in Caucasian Men With Androgenetic Alopecia

October 2015 in “ Journal of Dermatology ”

Tokuro Iwabuchi, Ritsuro Ideta, Ritsuko Ehama, Haruyo Yamanishi, Masato Iino, Yosuke Nakazawa, Takashi Kobayashi, Manabu Ohyama, Jiro Kishimoto

topical adenosine androgenetic alopecia hair density hair diameter minoxidil Rogaine

TLDR Adenosine treatment thickens hair in Caucasian men with hair loss.

The study found that topical adenosine treatment can increase the proportion of thick hair in Caucasian men with androgenetic alopecia. The treatment was effective in improving hair density, hair diameter, and overall appearance after 6 months of treatment. Adenosine did not cause any adverse effects on Caucasian men and may be a useful alternative to minoxidil.

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Research cited in this study

9 / 9 results

research Topical Adenosine Increases Thick Hair Ratio in Japanese Men with Androgenetic Alopecia

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Adenosine helps grow thicker hair in Japanese men with hair loss.

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Adenosine Increases Anagen Hair Growth And Thick Hairs In Japanese Women With Female Pattern Hair Loss: A Pilot, Double-Blind, Randomized, Placebo-Controlled Trial

research Adenosine Increases Anagen Hair Growth And Thick Hairs In Japanese Women With Female Pattern Hair Loss: A Pilot, Double-Blind, Randomized, Placebo-Controlled Trial

33 citations, December 2008 in “Journal of Dermatology”

Adenosine lotion improves hair growth and thickness in women with hair loss.

research Adenosine Stimulates Fibroblast Growth Factor-7 Gene Expression Via Adenosine A2b Receptor Signaling in Dermal Papilla Cells

66 citations, February 2007 in “The journal of investigative dermatology/Journal of investigative dermatology”

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A Randomized Clinical Trial of 5% Topical Minoxidil Versus 2% Topical Minoxidil and Placebo in the Treatment of Androgenetic Alopecia in Men

research A Randomized Clinical Trial of 5% Topical Minoxidil Versus 2% Topical Minoxidil and Placebo in the Treatment of Androgenetic Alopecia in Men

269 citations, August 2002 in “Journal of The American Academy of Dermatology”

5% minoxidil works better for hair growth and density, with minor irritation.

Minoxidil-Induced Hair Growth Is Mediated by Adenosine in Cultured Dermal Papilla Cells: Possible Involvement of Sulfonylurea Receptor 2B as a Target of Minoxidil

research Minoxidil-Induced Hair Growth Is Mediated by Adenosine in Cultured Dermal Papilla Cells: Possible Involvement of Sulfonylurea Receptor 2B as a Target of Minoxidil

83 citations, December 2001 in “Journal of Investigative Dermatology”

Minoxidil boosts hair growth by targeting adenosine and possibly sulfonylurea receptor 2B.

research Histologic Response to Topically Applied Minoxidil in Male-Pattern Alopecia

38 citations, October 1988 in “Clinics in Dermatology”

Minoxidil can help grow hair and make hair follicles bigger, but it can also cause side effects.

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Comparing the effectiveness of minoxidil 5% and adenosine 0.75% for treating male androgenetic alopecia, and measuring patient satisfaction rate; results showed that adenosine is comparable to minoxidil but provides quicker results, however availability of products with adenosine is much less than those with minoxidil.

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Topical Adenosine Increases the Proportion of Thick Hair in Caucasian Men With Androgenetic Alopecia

Research cited in this study

research Topical Adenosine Increases Thick Hair Ratio in Japanese Men with Androgenetic Alopecia

research Contribution of Hair Density and Hair Diameter to the Appearance and Progression of Androgenetic Alopecia in Japanese Men

research Minoxidil Use in Dermatology, Side Effects, and Recent Patents

research Randomized Clinical Trial Comparing 5% and 1% Topical Minoxidil for the Treatment of Androgenetic Alopecia in Japanese Men

research Adenosine Increases Anagen Hair Growth And Thick Hairs In Japanese Women With Female Pattern Hair Loss: A Pilot, Double-Blind, Randomized, Placebo-Controlled Trial

research Adenosine Stimulates Fibroblast Growth Factor-7 Gene Expression Via Adenosine A2b Receptor Signaling in Dermal Papilla Cells

research A Randomized Clinical Trial of 5% Topical Minoxidil Versus 2% Topical Minoxidil and Placebo in the Treatment of Androgenetic Alopecia in Men

research Minoxidil-Induced Hair Growth Is Mediated by Adenosine in Cultured Dermal Papilla Cells: Possible Involvement of Sulfonylurea Receptor 2B as a Target of Minoxidil

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