Topical Adenosine Increases the Proportion of Thick Hair in Caucasian Men With Androgenetic Alopecia

October 2015 in “ Journal of Dermatology ”

Tokuro Iwabuchi, Ritsuro Ideta, Ritsuko Ehama, Haruyo Yamanishi, Masato Iino, Yosuke Nakazawa, Takashi Kobayashi, Manabu Ohyama, Jiro Kishimoto

topical adenosine androgenetic alopecia hair density hair diameter minoxidil Rogaine

Studysummary This study found that adenosine significantly increased the proportion of thick hair in Caucasian men with androgenetic alopecia, with no reported adverse effects.

Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer

The study found that topical adenosine treatment can increase the proportion of thick hair in Caucasian men with androgenetic alopecia. The treatment was effective in improving hair density, hair diameter, and overall appearance after 6 months of treatment. Adenosine did not cause any adverse effects on Caucasian men and may be a useful alternative to minoxidil.

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Research cited in this study

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research Topical Adenosine Increases Thick Hair Ratio in Japanese Men with Androgenetic Alopecia

11 citations , April 2015 in “International Journal of Cosmetic Science”

This study found that topical adenosine significantly increased the ratio of thick hairs and contributed to global improvement in Japanese men with androgenetic alopecia compared to niacinamide, with no observed adverse events.

research Contribution of Hair Density and Hair Diameter to the Appearance and Progression of Androgenetic Alopecia in Japanese Men

21 citations , July 2014 in “British Journal of Dermatology”

In this study, hair loss in Japanese men with androgenetic alopecia was found to be primarily due to hair follicle miniaturization rather than hair shedding, particularly in those aged 25 and older.

research Minoxidil Use in Dermatology, Side Effects, and Recent Patents

152 citations , April 2012 in “Recent Patents on Inflammation & Allergy Drug Discovery”

This review describes minoxidil's hair regrowth mechanism and discusses dermatological applications, but reports no new clinical results, emphasizing the need for regular use and addressing allergic reactions.

research Randomized Clinical Trial Comparing 5% and 1% Topical Minoxidil for the Treatment of Androgenetic Alopecia in Japanese Men

29 citations , July 2009 in “Journal of Dermatology”

This study confirmed that 5% topical minoxidil is more effective than 1% in increasing hair density in Japanese men with androgenetic alopecia, with no significant difference in adverse event rates.

Adenosine Increases Anagen Hair Growth And Thick Hairs In Japanese Women With Female Pattern Hair Loss: A Pilot, Double-Blind, Randomized, Placebo-Controlled Trial

research Adenosine Increases Anagen Hair Growth And Thick Hairs In Japanese Women With Female Pattern Hair Loss: A Pilot, Double-Blind, Randomized, Placebo-Controlled Trial

33 citations , December 2008 in “Journal of Dermatology”

This study found that 0.75% adenosine lotion significantly improved hair growth and thickness in Japanese women with female pattern hair loss compared to a placebo.

research Adenosine Stimulates Fibroblast Growth Factor-7 Gene Expression Via Adenosine A2b Receptor Signaling in Dermal Papilla Cells

66 citations , February 2007 in “The journal of investigative dermatology/Journal of investigative dermatology”

The researchers reported that adenosine increases FGF-7 expression in dermal papilla cells, which may stimulate hair growth via the A2b adenosine receptor and cAMP pathway.

A Randomized Clinical Trial of 5% Topical Minoxidil Versus 2% Topical Minoxidil and Placebo in the Treatment of Androgenetic Alopecia in Men

research A Randomized Clinical Trial of 5% Topical Minoxidil Versus 2% Topical Minoxidil and Placebo in the Treatment of Androgenetic Alopecia in Men

269 citations , August 2002 in “Journal of The American Academy of Dermatology”

This study found that 5% topical minoxidil significantly increased hair regrowth and improved psychosocial perceptions of hair loss in men with androgenetic alopecia compared to 2% topical minoxidil and placebo over 48 weeks.

Minoxidil-Induced Hair Growth Is Mediated by Adenosine in Cultured Dermal Papilla Cells: Possible Involvement of Sulfonylurea Receptor 2B as a Target of Minoxidil

research Minoxidil-Induced Hair Growth Is Mediated by Adenosine in Cultured Dermal Papilla Cells: Possible Involvement of Sulfonylurea Receptor 2B as a Target of Minoxidil

83 citations , December 2001 in “Journal of Investigative Dermatology”

Minoxidil boosts hair growth by targeting adenosine and possibly sulfonylurea receptor 2B.

research Histologic Response to Topically Applied Minoxidil in Male-Pattern Alopecia

38 citations , October 1988 in “Clinics in Dermatology”

Minoxidil can help grow hair and make hair follicles bigger, but it can also cause side effects.