Dexpanthenol Promotes Cell Growth by Preventing Cell Senescence and Apoptosis in Cultured Human Hair Follicle Cells

    September 2021 in “ Current Issues in Molecular Biology ”
    Jae Young Shin, Jaeyoon Kim, Yun-Ho Choi, Nae Gyu Kang, Sanghwa Lee
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    TLDR Dexpanthenol helps human hair follicle cells grow by preventing aging and death, and by supporting growth signals.
    The study found that Dexpanthenol, a precursor of vitamin B5, promotes cell growth in human hair follicle cells by preventing cell senescence (aging) and apoptosis (cell death). It reduced the expression of apoptosis markers caspase 3 and caspase 9, and senescence markers p21 and p16. It also increased the expression of anagen (growth phase) markers, alkaline phosphatase (ALP) and β-catenin, and decreased the expression of TGF-β1, a protein that stimulates hair follicles to enter the catagen (regression) phase. Furthermore, Dexpanthenol stimulated the expression of VEGF, a protein that promotes hair growth, and its receptor in human outer root sheath cells (hORSCs), suggesting that Dexpanthenol induces the proliferation of hORSCs through VEGF signaling.
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