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research Dexpanthenol Promotes Cell Growth by Preventing Cell Senescence and Apoptosis in Cultured Human Hair Follicle Cells

13 citations , September 2021 in “Current Issues in Molecular Biology”

This study suggests that D-panthenol may promote hair growth by enhancing cell viability, suppressing apoptosis markers, and elongating the anagen phase in human hair follicle cells.

research Sustained Human Hair Follicle Growth Ex Vivo in a Glycosaminoglycan Hydrogel Matrix

9 citations , April 2019 in “International journal of molecular sciences”

In this study, growing human hair follicles in a defined glycosaminoglycan hydrogel ex vivo promoted cell survival, proliferation, and activation of hair growth-related signaling pathways, suggesting GAG-based hydrogels could modulate the hair follicle growth cycle.

Intrinsic Activation of Cell Growth and Differentiation in Ex Vivo Cultured Human Hair Follicles by a Transient Endogenous Production of ROS

research Intrinsic activation of cell growth and differentiation in ex vivo cultured human hair follicles by a transient endogenous production of ROS

9 citations , March 2019 in “Scientific reports”

This study found that transient non-lethal levels of endogenous ROS in cultured human hair follicles promoted entry into the growth phase by activating the hair follicle stem cell niche.

research Faculty Opinions recommendation of Autologous platelet-rich plasma: a potential therapeutic tool for promoting hair growth.

July 2012 in “Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature”

In this study, researchers observed that activated platelet-rich plasma promoted hair growth in mice and increased cell proliferation in vitro, suggesting potential clinical applications for hair growth treatment.

research De Novo Production of Dermal Papilla Cells during the Anagen Phase of the Hair Cycle

41 citations , June 2010 in “Journal of Investigative Dermatology”

This study suggests that new cells are incorporated into the dermal papilla during the early anagen phase of the hair cycle, which may influence hair growth consistency and follicle size changes.

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community GT20029 China Phase II Trial For AGA Reached Primary Endpoint

133 upvotes 2 years ago

The GT20029 tincture, a topical androgen receptor degrader, showed significant hair growth and good safety in a China Phase II trial for male androgenetic alopecia (AGA), with the 1% dose twice weekly identified as optimal. The company plans to initiate Phase III trials in China and Phase II in the U.S., and the treatment also shows promise for acne.

community Did Scientists Just Cure Baldness? UCLA’s New Molecule Could Revolutionize Hair Growth

559 upvotes 1 year ago

PP405 shows promise for hair growth but may need continuous use like Minoxidil. Current treatments include Minoxidil, finasteride, and dutasteride, with skepticism about a true cure due to financial interests.

community Hair loss research focused on chemistry for decades because we misunderstood the mechanics of growth.

51 upvotes 7 months ago

Hair growth relies on mechanical forces, not just chemicals, with tissue acting like a motor. Minoxidil and finasteride help, but maintaining tissue elasticity and addressing mechanical issues are essential.

community KX-826 Phase 3 Failed. Sorry guys...

51 upvotes 2 years ago

The conversation discusses the failure of Phase 3 trials for the hair loss treatment KX-826, with no significant difference found between the drug and placebo. Some users express disappointment and skepticism, while others discuss alternative treatments like Minoxidil, finasteride, and RU58841.

community When could we expect pp405 to hit the market?

31 upvotes 1 year ago

PP405 is expected to finish Phase 2 trials in late 2025, with potential market availability around 2028-2029 if all goes well. Current treatments like finasteride and minoxidil are still popular, while new options like KX-826 and Breezula are anticipated soon.

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Learn

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learn Adenosine

nucleoside used for hair regrowth stimulant properties

learn Dexpanthenol

precursor of vitamin B5 with hair stimulating effects

learn sh-Polypeptide-7

learn Osteopontin

signaling protein that, when suppressed, may grow hair by reducing inflammation and stem cell loss

learn Hair Transplant

What happens after a hair transplant? Expect mild swelling and redness, with new hair growth starting in 3 to 6 months.
How long does a hair transplant procedure take? A hair transplant procedure typically takes 4 to 8 hours.

learn Stemoxydine

chemical from L'Oreal that encourages hair to enter growth phase

How does stemoxydine help stimulate new hair growth on the scalp? Stemoxydine stimulates new hair growth by promoting hair follicles to transition from the resting phase to the active growth phase.

learn Platelet-Rich Plasma

What is Platelet-Derived Growth Factor Beta Polypeptide, and how does it help stimulate new hair growth? PDGF-BB is a growth factor that signals to dermal papilla cells and promotes blood-vessel formation; mouse studies report it can push follicles into the growth phase, and human evidence comes only indirectly from PRP trials. No PDGF product is approved for hair restoration and there is no published human trial of PDGF-BB on its own.

learn Bimatoprost

Can a lash-growth serum like bimatoprost actually work for your scalp? Bimatoprost (Latisse) is approved for eyelashes, not the scalp; two Allergan phase 2 trials in men with androgenetic alopecia posted results to ClinicalTrials.gov but were never published in a peer-reviewed journal, so scalp use remains off-label and experimental.

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Clinics

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Hair Systems
Mane PhaseRancho Cucamonga, CA · US

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