VEGFR-2 Is in a State of Activation in Hair Follicles, Sebaceous Glands, Eccrine Sweat Glands, and Epidermis from Human Scalp: An In Situ Immunohistochemistry Study of Phosphorylated VEGFR-2

March 2019 in “ Medical science monitor basic research/Medical science monitor. Basic research ”

Xianjie Wu, Jing Jing, Lu Zhang, Min Zheng

VEGFR-2 hair follicles sebaceous glands eccrine sweat glands epidermis phosphorylated VEGFR-2 in situ immunohistochemistry vascular endothelial growth factor receptor 2 sweat glands skin activated VEGFR-2 immunohistochemistry

Studysummary This study found that phosphorylated VEGFR-2 is present in human scalp epidermal appendages and suggests it plays a role in their daily regulation. Our plain-language summary of this paper — not a Tressless recommendation.

The study found that VEGFR-2 was activated in hair follicles, sebaceous glands, eccrine sweat glands, and the epidermis of the human scalp, as shown by in situ immunohistochemistry detecting phosphorylated VEGFR-2. This activation suggested a role for VEGFR-2 in the physiological processes of these structures, potentially influencing hair growth and scalp health. The study included scalp specimens from 11 donors aged 20-35 years, indicating that VEGFR-2 signaling might be crucial for the routine functions of the epidermis and its appendages, though further research was needed to understand the specific regulatory mechanisms.

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Research cited in this study

6 / 6 results

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