VEGFR-2 Is in a State of Activation in Hair Follicles, Sebaceous Glands, Eccrine Sweat Glands, and Epidermis from Human Scalp: An In Situ Immunohistochemistry Study of Phosphorylated VEGFR-2

March 2019 in “ Medical science monitor basic research/Medical science monitor. Basic research ”

Xianjie Wu, Jing Jing, Lu Zhang, Min Zheng

VEGFR-2 hair follicles sebaceous glands eccrine sweat glands epidermis phosphorylated VEGFR-2 in situ immunohistochemistry vascular endothelial growth factor receptor 2 sweat glands skin activated VEGFR-2 immunohistochemistry

TLDR VEGFR-2 is active in hair follicles, sebaceous glands, sweat glands, and skin on the human scalp.

The study found that VEGFR-2 was activated in hair follicles, sebaceous glands, eccrine sweat glands, and the epidermis of the human scalp, as shown by in situ immunohistochemistry detecting phosphorylated VEGFR-2. This activation suggested a role for VEGFR-2 in the physiological processes of these structures, potentially influencing hair growth and scalp health. The study included scalp specimens from 11 donors aged 20-35 years, indicating that VEGFR-2 signaling might be crucial for the routine functions of the epidermis and its appendages, though further research was needed to understand the specific regulatory mechanisms.

View this study on europepmc.org →

Discuss this study in the Community →

Research cited in this study

3 / 3 results

research Beyond Acne: Current Aspects of Sebaceous Gland Biology and Function

97 citations, September 2016 in “Reviews in Endocrine and Metabolic Disorders”

The sebaceous gland has more roles than just producing sebum and contributing to acne, and new research could lead to better skin disease treatments.

research Paracrine Crosstalk Between Human Hair Follicle Dermal Papilla Cells and Microvascular Endothelial Cells

35 citations, March 2015 in “Experimental Dermatology”

Cells from the base of hair follicles help blood vessel cells survive and grow, which is important for healthy hair.

research VEGF Upregulates VEGF Receptor-2 on Human Outer Root Sheath Cells and Stimulates Proliferation Through ERK Pathway

23 citations, June 2012 in “Molecular Biology Reports”

VEGF stimulates hair cell growth and increases growth receptor levels through a specific signaling pathway.

Related Research

1 / 1 results

research The Secretory Clear Cell of the Eccrine Sweat Gland as the Probable Source of Excess Sweat Production in Hyperhidrosis

36 citations, August 2011 in “Experimental Dermatology”

Eccrine sweat gland's clear cells likely cause excessive sweating in hyperhidrosis.

VEGFR-2 Is in a State of Activation in Hair Follicles, Sebaceous Glands, Eccrine Sweat Glands, and Epidermis from Human Scalp: An In Situ Immunohistochemistry Study of Phosphorylated VEGFR-2

Research cited in this study

research Beyond Acne: Current Aspects of Sebaceous Gland Biology and Function

research Paracrine Crosstalk Between Human Hair Follicle Dermal Papilla Cells and Microvascular Endothelial Cells

research VEGF Upregulates VEGF Receptor-2 on Human Outer Root Sheath Cells and Stimulates Proliferation Through ERK Pathway

Related Community Posts Join

community Oral minoxidil is not good for your health, let’s use research chemicals bought from AliExpress

community Growth factors, VEGF, And more,possible permanent cure for people with moderate hairloss?

community New and Interesting HairLoss Studies/Papers/Reviews

community Surprisingly thorough study on He-Shou-Wu/Fo Ti

community Fin/min/microneedling ~9 months – no results, actually worse

community 2 years later I managed to gain some ground (Hyperresponder)

Related Research

research The Secretory Clear Cell of the Eccrine Sweat Gland as the Probable Source of Excess Sweat Production in Hyperhidrosis